Nishikawa Yuichi, Watanabe Kohei, Takahashi Tetsuya, Orita Naoya, Kimura Hiroaki, Matsumoto Masayasu, Maruyama Hirofumi
Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan; Division of Rehabilitation, Department of Clinical Practice and Support, Hiroshima University Hospital, Japan.
Laboratory of Neuromuscular Biomechanics, School of International Liberal Studies, Chukyo University, Japan.
J Electromyogr Kinesiol. 2017 Dec;37:125-131. doi: 10.1016/j.jelekin.2017.10.003. Epub 2017 Oct 19.
Parkinson's disease (PD) related decreases in muscle strength may result from both central and peripheral factors. However, the effect of PD on the neuromuscular system, such as motor unit activation properties, remains unclear. The purpose of the present study was to compare the spatial distribution pattern of electromyographic activity during sustained contractions in healthy subjects and PD patients. Twenty-five female PD patients and 25 healthy age-matched female control subjects performed ramp submaximal contractions during an isometric knee extension from 20% to 80% of the maximal voluntary contraction (MVC). To evaluate alterations in the spatial electromyography (EMG) potential distribution, normalized root mean square (RMS), modified entropy, coefficient of variation, and correlation coefficients were calculated from multi-channel surface electromyography at 10% force increments. The comparison between PD and healthy subjects revealed that, during increased force exertions, PD patients exhibited less change in normalized RMS, modified entropy, coefficient of variation, and pattern of spatial EMG distribution. These data showed that the heterogeneity and the changes in the activation pattern are smaller in the PD patients than in healthy subjects. This finding may be associated with central adaptation and/or peripheral changes in PD patients.
帕金森病（PD）相关的肌肉力量下降可能由中枢和外周因素共同导致。然而，PD对神经肌肉系统的影响，如运动单位激活特性，仍不清楚。本研究的目的是比较健康受试者和PD患者在持续收缩过程中肌电图活动的空间分布模式。25名女性PD患者和25名年龄匹配的健康女性对照受试者在等长膝关节伸展过程中，从最大自主收缩（MVC）的20%到80%进行斜坡次最大收缩。为了评估空间肌电图（EMG）电位分布的变化，在力量以10%的增量增加时，从多通道表面肌电图计算归一化均方根（RMS）、修正熵、变异系数和相关系数。PD患者与健康受试者之间的比较显示，在用力增加期间，PD患者的归一化RMS、修正熵、变异系数和空间EMG分布模式变化较小。这些数据表明，PD患者的异质性和激活模式变化比健康受试者小。这一发现可能与PD患者的中枢适应和/或外周变化有关。
