Nishikawa Yuichi, Watanabe Kohei, Takahashi Tetsuya, Kimura Hiroaki, Maruyama Hirofumi
Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan; Division of Rehabilitation, Department of Clinical Practice and Support, Hiroshima University Hospital, Hiroshima, Japan.
Laboratory of Neuromuscular Biomechanics, School of International Liberal Studies, Chukyo University, Nagoya, Japan.
J Electromyogr Kinesiol. 2018 Oct;42:66-73. doi: 10.1016/j.jelekin.2018.06.014. Epub 2018 Jun 25.
The effect of levodopa on muscle activity patterns in Parkinson's disease (PD) patients is currently unclear. The aim of the present study was to compare the spatial distribution pattern of electromyographic activity during sustained isometric contraction in PD patients during on- and off-medication periods using multi-channel surface electromyography (SEMG). Ten female PD patients were recruited for the present study. All patients performed a sustained isometric knee extension at 10% maximum voluntary contraction task for 60 s. To evaluate alterations in the spatial SEMG potential distribution, the coefficient of variation (CV) of force, normalized root mean square (RMS), modified entropy, CV of the RMS, and correlation coefficients were calculated at during contraction task. The off-medication period exhibited more fluctuation during the contraction task than those in the on-medication period. The off-medication period exhibited less change in modified entropy, the CV of RMS, the correlation coefficient and patterns of spatial SEMG distribution. These data demonstrated that the heterogeneity and changes in the activation pattern are smaller in the off-medication period than in those in the on-medication period. These findings might indicate that levodopa enhanced the activation of muscle action potentials during force production.
左旋多巴对帕金森病（PD）患者肌肉活动模式的影响目前尚不清楚。本研究的目的是使用多通道表面肌电图（SEMG）比较PD患者在服药期和停药期持续等长收缩期间肌电活动的空间分布模式。本研究招募了10名女性PD患者。所有患者以最大自主收缩的10%进行持续60秒的等长伸膝任务。为了评估空间SEMG电位分布的变化，在收缩任务期间计算了力的变异系数（CV）、归一化均方根（RMS）、修正熵、RMS的CV以及相关系数。停药期在收缩任务期间比服药期表现出更多波动。停药期在修正熵、RMS的CV、相关系数和空间SEMG分布模式方面变化较小。这些数据表明，停药期激活模式的异质性和变化比服药期小。这些发现可能表明左旋多巴在力量产生过程中增强了肌肉动作电位的激活。
