青春期前患者的睾丸肿瘤。

Testicular tumors in prepubescent patients.

作者信息

Maizlin Ilan I, Dellinger Matthew, Gow Kenneth W, Goldin Adam B, Goldfarb Melanie, Nuchtern Jed G, Langer Monica, Vasudevan Sanjeev A, Doski John J, Raval Mehul V, Beierle Elizabeth A

机构信息

Department of Surgery, University of Alabama at Birmingham, 1600 7th Ave S, Lowder Room 300, Birmingham, AL 35233.

Division of Pediatric General and Thoracic Surgery, Seattle Children's Hospital, 4800 Sand, Point Way NE, Seattle, WA.

出版信息

J Pediatr Surg. 2018 Sep;53(9):1748-1752. doi: 10.1016/j.jpedsurg.2017.09.020. Epub 2017 Oct 8.

DOI:10.1016/j.jpedsurg.2017.09.020

PMID:29102152

Abstract

BACKGROUND/PURPOSE: Pediatric testicular tumors are rare, constituting only 1% of all pediatric solid tumors. Single-institution studies addressing pediatric testicular tumors published to date have been limited in the number of patients.

METHODS

We utilized the National Cancer Data Base (1998-2012) to review all prepubescent patients (≤12 years old) with testicular neoplasms. Demographics, tumor characteristics, treatment modalities, and outcomes were abstracted.

RESULTS

A total of 479 patients were identified, with a median age of 3 years (IQR 0-4) at diagnosis. 67% of cases were diagnosed by 3 years of age. Yolk sac tumors were the most common histology (202 patients, 42.2%). Most tumors were diagnosed at a low stage. Resection was performed in 465 boys, with 75% having undergone radical orchiectomies. Chemotherapy was utilized in 28% of cases and radiotherapy in 7%. With mean follow-up of 5.6 years, mortality rate was 3%. No difference in mortality was noted based on histology or extent of surgical resection.

CONCLUSIONS

This series of prepubertal testicular tumors is the largest yet reported and highlights the patient demographics, tumor characteristics, treatment modalities and outcomes for these tumors.

TYPE OF STUDY

Prognosis study LEVEL OF EVIDENCE: II.

摘要

背景/目的：小儿睾丸肿瘤较为罕见，仅占所有小儿实体瘤的1%。迄今为止，已发表的关于小儿睾丸肿瘤的单机构研究的患者数量有限。

方法

我们利用国家癌症数据库（1998 - 2012年）对所有青春期前（≤12岁）睾丸肿瘤患者进行回顾。提取了人口统计学、肿瘤特征、治疗方式和结果等信息。

结果

共确定479例患者，诊断时的中位年龄为3岁（四分位间距0 - 4岁）。67%的病例在3岁前被诊断。卵黄囊瘤是最常见的组织学类型（202例，42.2%）。大多数肿瘤在低分期时被诊断。465名男孩接受了手术切除，其中75%接受了根治性睾丸切除术。28%的病例使用了化疗，7%使用了放疗。平均随访5.6年，死亡率为3%。基于组织学或手术切除范围，未观察到死亡率的差异。