Bägli D J, Steele G D, Barlozzari T
Department of Surgery, New England Deaconess Hospital, Boston, MA 02115.
Arch Surg. 1989 Jan;124(1):89-93. doi: 10.1001/archsurg.1989.01410010099020.
Lymphocytes with natural killer (NK) ability recognize a wide range of target cells; however, the mediators of specific target recognition are still largely unknown. Despite the diversity of the NK target repertoire, it is typified by cells of relatively immature phenotype. The purpose of this study was to determine if colorectal carcinoma (CRC) targets were sensitive to spontaneous lysis by fresh human NK effector cells and to observe the role of CRC differentiation in this process. Results demonstrated that poorly differentiated CRC targets were susceptible to NK-mediated lysis whereas CRC targets with more differentiated structure were NK resistant. In addition, chemical induction of a more mature CRC phenotype confers NK resistance on a previously NK-susceptible target. This maturation-related modulation of NK sensitivity can provide a model with which to further study interaction between NK cells and CRC targets.
具有自然杀伤（NK）能力的淋巴细胞可识别多种靶细胞；然而，特异性靶细胞识别的介质在很大程度上仍不清楚。尽管NK靶细胞库具有多样性，但其典型特征是相对不成熟表型的细胞。本研究的目的是确定结直肠癌（CRC）靶细胞对新鲜人NK效应细胞的自发裂解是否敏感，并观察CRC分化在此过程中的作用。结果表明，低分化的CRC靶细胞易受NK介导的裂解，而结构更分化的CRC靶细胞对NK具有抗性。此外，化学诱导更成熟的CRC表型可使先前对NK敏感的靶细胞产生NK抗性。这种与成熟相关的NK敏感性调节可为进一步研究NK细胞与CRC靶细胞之间的相互作用提供一个模型。
