戒烟与后续癌症风险：日本八项基于人群的队列研究的汇总分析。

Smoking cessation and subsequent risk of cancer: A pooled analysis of eight population-based cohort studies in Japan.

作者信息

Saito Eiko, Inoue Manami, Tsugane Shoichiro, Ito Hidemi, Matsuo Keitaro, Wakai Kenji, Wada Keiko, Nagata Chisato, Tamakoshi Akiko, Sugawara Yumi, Tsuji Ichiro, Mizoue Tetsuya, Tanaka Keitaro, Sasazuki Shizuka

机构信息

Department of Global Health Policy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.

Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.

出版信息

Cancer Epidemiol. 2017 Dec;51:98-108. doi: 10.1016/j.canep.2017.10.013. Epub 2017 Nov 5.

DOI:10.1016/j.canep.2017.10.013

PMID:29102692

Abstract

BACKGROUND

Although East Asia is one of the largest tobacco-epidemic regions in the world, only a few prospective studies from Asia have investigated the impact of smoking and cessation of smoking on cancer. We aimed to assess the effect of cessation of smoking on the risk of cancer using eight population-based cohort studies in Japan.

METHODS

We analyzed pooled data from eight population-based prospective cohort studies in Japan with more than 320,000 participants to assess the effect of smoking cessation on the risk of total cancers and smoking-related cancers.

RESULTS

After adjustment for potential confounders, cancer risks in men with >21years of smoking cessation before baseline were found to decrease to the same level as never smokers for total cancer (never smokers: reference; former smokers with ≥21 years since smoking cessation: HR, 1.01; 95%CI: 0.91, 1.11). Even men who are heavy smokers (more than 20 pack-years) reported a reduced risk of total cancer (never smokers: reference; former smokers with ≥21 years since smoking cessation: HR, 1.06; 95%CI: 0.92, 1.23). In women, the risk of total cancer did not differ from that of never smokers after 11 years of smoking cessation before baseline (never smokers: reference; former smokers with ≥11 years since smoking cessation: HR, 0.96; 95%CI: 0.74, 1.23).

CONCLUSIONS

Our study suggests that longer duration of smoking cessation may attenuate the risk of cancer in both men and women, and that even heavy smokers (more than 20 pack-years) were found to benefit from quitting smoking.

摘要

背景

尽管东亚是世界上最大的烟草流行地区之一，但亚洲仅有少数前瞻性研究调查了吸烟及戒烟对癌症的影响。我们旨在利用日本的八项基于人群的队列研究评估戒烟对癌症风险的影响。

方法

我们分析了日本八项基于人群的前瞻性队列研究的汇总数据，这些研究的参与者超过32万，以评估戒烟对总体癌症及吸烟相关癌症风险的影响。

结果

在对潜在混杂因素进行调整后，发现基线前戒烟超过21年的男性患总体癌症的风险降至与从不吸烟者相同的水平（从不吸烟者：参照组；戒烟后≥21年的既往吸烟者：风险比，1.01；95%置信区间：0.91，1.11）。即使是重度吸烟者（超过20包年），其患总体癌症的风险也有所降低（从不吸烟者：参照组；戒烟后≥21年的既往吸烟者：风险比，1.06；95%置信区间：0.92，1.23）。在女性中，基线前戒烟11年后，其患总体癌症的风险与从不吸烟者无异（从不吸烟者：参照组；戒烟后≥11年的既往吸烟者：风险比，0.96；95%置信区间：0.74，1.23）。