Carnero Contentti Edgar, Genco Néstor David, Hryb Javier Pablo, Caspi Mercedes, Chiganer Edson, Di Pace José Luis, López Pablo Adrián, Lessa Carmen, Caride Alejandro, Perassolo Mónica
Section of Neurology, Hospital Carlos G. Durand, Buenos Aires, Argentina; Department of Neuroscience, Neuroimmunology Unit, Hospital Alemán, Buenos Aires, Argentina.
Neurology Service, Hospital Lagomaggiore, Mendoza, Argentina.
Clin Neurol Neurosurg. 2017 Dec;163:149-155. doi: 10.1016/j.clineuro.2017.10.032. Epub 2017 Oct 31.
To report the impact of multiple sclerosis (MS) on patients' quality of life (QoL) compared to systemic lupus erythematosus (SLE) using the 36-Item Short Form (SF-36) health questionnaire in Argentina.
Cross-sectional study. All consecutive MS patients, SLE and healthy controls (HC) were included. Demographics, clinical and radiological aspects, EDSS and SF-36 were assessed.
A total of 191 subjects were included (MS=74, SLE=30 and HC=87). When we compared, using 2 standard deviations below the normal mean, the SF-36 subscales scores between MS and SLE, we found that MS patients experienced significant deterioration in general health (p<0.0001), vitality (p=0.009), current health (p<0.0001) and previous year health perception (p=0.003). Additional evaluated areas did not show significant differences. MS patients scored significantly lower in all categories compared to HC, except for bodily pain. An inverse correlation between EDSS and SF-36 total (R=0.59, β -11.08, p<0.0001) and subscale scores was observed after applying regression analysis.
MS behaves as a systemic disease from the functional point of view. Patient-reported QoL scales scores provide comprehensive additional prognostic information beyond the EDSS score. Therefore, adding the SF-36 questionnaire in clinical practice might be useful for the assessment and follow-up of MS patients.
在阿根廷使用36项简明健康调查问卷（SF-36）报告与系统性红斑狼疮（SLE）相比，多发性硬化症（MS）对患者生活质量（QoL）的影响。
横断面研究。纳入所有连续的MS患者、SLE患者和健康对照（HC）。评估人口统计学、临床和放射学方面、扩展残疾状态量表（EDSS）和SF-36。
共纳入191名受试者（MS=74例，SLE=30例，HC=87例）。当我们使用低于正常均值2个标准差来比较MS和SLE之间的SF-36分量表得分时，我们发现MS患者在总体健康（p<0.0001）、活力（p=0.009）、当前健康（p<0.0001）和前一年健康感知（p=0.003）方面出现了显著恶化。其他评估领域未显示出显著差异。与HC相比，MS患者在所有类别中的得分均显著较低，但身体疼痛除外。应用回归分析后，观察到EDSS与SF-36总分（R=0.59，β=-11.08，p<0.0001）及分量表得分之间呈负相关。
从功能角度来看，MS表现为一种全身性疾病。患者报告的QoL量表得分提供了超出EDSS评分的全面额外预后信息。因此，在临床实践中增加SF-36问卷可能有助于MS患者的评估和随访。
