Department of Production Animal Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort 0110, South Africa; National Veterinary Research Institute, Vom, Nigeria.
National Veterinary Research Institute, Vom, Nigeria.
Infect Genet Evol. 2018 Jan;57:98-105. doi: 10.1016/j.meegid.2017.10.027. Epub 2017 Nov 15.
Phylogenetic analyses of the complete genomes of the highly pathogenic avian influenza (HPAI) 2.3.2.1c H5N1 virus strains causing outbreaks in Nigeria's poultry population from 2014 to 2016 showed evidence of distinct co-circulating genotypes and the emergence of reassortant viruses. One of these reassortants became the predominant strain by 2016, and the NA protein of this strain possessed the V96A substitution known to confer reduced susceptibility to neuraminidase inhibiting antiviral drugs. Our findings also demonstrated evolutionary relationships between Nigerian isolates and European and Middle Eastern strains of H5N1 which provides further evidence for the proposed role of migratory birds in spreading the virus, although the involvement of the live poultry trade cannot be excluded. Efforts must be directed towards improving biosecurity and gaining the cooperation of poultry farmers for more effective control of HPAI, in order to mitigate the emergence of HPAI strains in Nigeria with biological properties that are potentially even more dangerous to animals and humans.
对导致尼日利亚家禽疫情爆发的高致病性禽流感（HPAI）2.3.2.1c H5N1 病毒株的全基因组进行系统进化分析表明，存在明显的共同循环基因型和重组病毒的出现。其中一种重组病毒在 2016 年成为主要流行株，该株的 NA 蛋白具有 V96A 取代，已知该取代会降低对神经氨酸酶抑制抗病毒药物的敏感性。我们的研究结果还表明，尼日利亚分离株与欧洲和中东的 H5N1 株之间存在进化关系，这进一步证明了候鸟在传播病毒方面的作用，尽管不能排除活禽贸易的参与。必须努力改善生物安全，并获得家禽养殖户的合作，以更有效地控制高致病性禽流感，从而减轻尼日利亚出现对动物和人类更具潜在危险的高致病性禽流感株的风险。
