Geisinger K R, Kute T E, Pettenati M J, Welander C E, Dennard Y, Collins L A, Berens M E
Department of Pathology, Wake Forest University, Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103.
Cancer. 1989 Jan 15;63(2):280-8. doi: 10.1002/1097-0142(19890115)63:2<280::aid-cncr2820630213>3.0.co;2-n.
The potential significant therapeutic and prognostic roles for the sex steroid receptors in ovarian cancer are recognized. The authors present in detail the biochemical, morphologic, cytogenetic, and growth characteristics of an ovarian carcinoma cell line, BG-1, which has functional estrogen and progesterone receptors (23 and 300 fmol/mg protein, respectively) in clinically significant levels. In particular, BG-1 has a DNA index of 1.14, a stable karyotype with specific translocations, and produces and secretes CA 125 into the media.
性类固醇受体在卵巢癌中潜在的重要治疗和预后作用已得到认可。作者详细介绍了一种卵巢癌细胞系BG-1的生化、形态学、细胞遗传学和生长特征，该细胞系具有临床上显著水平的功能性雌激素和孕激素受体（分别为23和300 fmol/mg蛋白）。特别是，BG-1的DNA指数为1.14，具有特定易位的稳定核型，并在培养基中产生和分泌CA 125。
