Li Zhen, Wang Xingling, Guan Yichun, Yu Xiaona, Liu Jing, Zhang Zhan
Reproductive Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Shangqiu Medical College, Shangqiu, Henan 476100, P.R. China.
Exp Ther Med. 2017 Nov;14(5):4797-4800. doi: 10.3892/etm.2017.5114. Epub 2017 Sep 8.
The purpose of this study was to investigate the clinical application of uterine artery blood flow parameters by vaginal color Doppler ultrasonography in patients with repeated embryo implantation failure and to examine the correlation between uterine artery blood flow parameters and microvessel density (MVD). We monitored the outcomes of fertilization and embryo transfer in eighty patients. We divided the patients into two groups: Pregnancy (successful pregnancy, n=50) and repeated implantation failure (more than two failures of fertilization-embryo transfer, n=30). The patients were subjected to vaginal color Doppler ultrasonography to measure endometrial thickness, peak systolic velocity/end diastolic velocity (S/D), pulsatility index (PI), resistance index (RI), and other uterine artery blood flow parameters. We found no significant differences in endometrial thickness (human chorionic gonadotropin endometrial thickness) and uterine artery blood flow parameters (S/D, PI) between the two groups. The RI value of endometrial blood flow was significantly higher in the repeated implantation failure group than that in pregnancy group. The endometrium MVD in the repeated implantation failure group was significantly lower than that of the pregnancy group. Spearman correlation analysis showed that S/D value of uterine artery blood flow in repeated implantation failure group was not correlated with MVD or uterine artery blood flow PI, but was positively correlated with RI. Endometrium MVD in patients with repeated implantation failure was significantly lower than that in patients with successful pregnancy during the implantation window. We also found a significant difference in uterine artery blood flow RI between the two groups. The uterine artery blood flow RI in patients with repeated implantation failure was positively correlated with MVD, which has clinical significance in predicting the outcome of embryo transfer.
本研究旨在探讨经阴道彩色多普勒超声检测子宫动脉血流参数在反复胚胎种植失败患者中的临床应用，并检测子宫动脉血流参数与微血管密度（MVD）之间的相关性。我们监测了80例患者的受精和胚胎移植结局。将患者分为两组：妊娠组（成功妊娠，n = 50）和反复种植失败组（受精-胚胎移植失败超过两次，n = 30）。对患者进行经阴道彩色多普勒超声检查，测量子宫内膜厚度、收缩期峰值流速/舒张末期流速（S/D）、搏动指数（PI）、阻力指数（RI）及其他子宫动脉血流参数。我们发现两组间子宫内膜厚度（人绒毛膜促性腺激素子宫内膜厚度）和子宫动脉血流参数（S/D、PI）无显著差异。反复种植失败组的子宫内膜血流RI值显著高于妊娠组。反复种植失败组的子宫内膜MVD显著低于妊娠组。Spearman相关性分析显示，反复种植失败组子宫动脉血流的S/D值与MVD或子宫动脉血流PI无相关性，但与RI呈正相关。反复种植失败患者在种植窗期的子宫内膜MVD显著低于成功妊娠患者。我们还发现两组间子宫动脉血流RI存在显著差异。反复种植失败患者的子宫动脉血流RI与MVD呈正相关，这对预测胚胎移植结局具有临床意义。
