Talbot R W, Nagorney D M, Pemberton J H, Wieand H S, Ritts R E
Department of Surgery, Mayo Clinic, Rochester, Minnesota 55905.
Cancer Res. 1989 Feb 1;49(3):542-3.
Synchronous serum specimens from the systemic and portal circulations of 43 patients with gastrointestinal cancer were assayed for levels of carcinoembryonic antigen, CA 19-9, and CA 125 tumor-associated antigens. The number of patients having a mean ratio of portal to systemic levels greater than 1 and the observed quantity of tumor-associated antigens were significant for carcinoembryonic antigen and CA 125 only in patients with colorectal cancer. No correlations were noted with the surgical stage of disease or with high or low (normal) levels of the three tumor-associated antigens. These findings suggest that peripheral concentrations of these antigens are in equilibrium with shedding from tumors and that hepatic clearance of a single pass does not significantly alter peripheral concentrations.
对43例胃肠道癌患者体循环和门静脉循环的同步血清标本进行癌胚抗原、CA 19-9和CA 125肿瘤相关抗原水平检测。门静脉与体循环水平平均比值大于1的患者数量以及观察到的肿瘤相关抗原量，仅在结直肠癌患者中，癌胚抗原和CA 125具有统计学意义。未发现与疾病手术分期或三种肿瘤相关抗原的高或低（正常）水平存在相关性。这些发现表明，这些抗原的外周浓度与肿瘤脱落处于平衡状态，单次通过肝脏清除不会显著改变外周浓度。
