Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland.
School of Health Sciences, Tampere University, Tampere, Finland.
Allergy. 2018 Apr;73(4):916-922. doi: 10.1111/all.13347. Epub 2017 Nov 28.
Five studies carried out after bronchiolitis at less than 24 months of age, with a follow-up of more than 10 years, reported that atopic dermatitis, family asthma, early-life exposure to tobacco smoke and rhinovirus aetiology were early-life risk factors for later asthma. This study evaluated the long-term outcome at 11-13 years of age of children who were hospitalized for bronchiolitis in early infancy.
We previously prospectively followed 166 children hospitalized for bronchiolitis at less than 6 months of age until 5-7 years of age. The current study included a structured questionnaire, parental interviews, clinical examinations and bronchodilation test of 138 of those children at 11-13 years of age.
Respiratory syncytial virus caused 66% of the bronchiolitis cases, and nearly half of the patients were exposed to tobacco smoke in early life. Doctor-diagnosed asthma was present in 13% of the former bronchiolitis patients at 11-13 years of age. Maternal asthma was the only independently significant risk factor in early life (adjusted OR 3.45, 95% CI 1.07-11.74), as was allergic rhinitis at 5-7 years of age (adjusted OR 4.06, 95% CI 1.35-12.25).
After bronchiolitis at less than 6 months of age, the risk of doctor-diagnosed asthma at 11-13 years was about twice that of the general Finnish population. Maternal asthma was the only independently significant early-life risk factor for current asthma at 11-13 years of age.
五项在小于 24 个月龄时发生毛细支气管炎，随访时间超过 10 年的研究报告称，特应性皮炎、家族哮喘、婴幼儿期接触烟草烟雾和鼻病毒病原是日后哮喘的早期生命危险因素。本研究评估了在婴幼儿早期因毛细支气管炎住院的儿童在 11-13 岁时的长期结局。
我们之前前瞻性地随访了 166 名在 6 个月龄以下因毛细支气管炎住院的儿童，直到他们 5-7 岁。目前的研究包括对其中 138 名儿童在 11-13 岁时进行了结构化问卷调查、父母访谈、临床检查和支气管扩张试验。
呼吸道合胞病毒引起了 66%的毛细支气管炎病例，近一半的患者在婴幼儿期接触了烟草烟雾。在 11-13 岁时，曾患有毛细支气管炎的患儿中有 13%被诊断为哮喘。母亲哮喘是婴幼儿期唯一独立的显著危险因素（调整后的 OR 3.45，95%CI 1.07-11.74），5-7 岁时患有过敏性鼻炎也是（调整后的 OR 4.06，95%CI 1.35-12.25）。
在小于 6 个月龄时发生毛细支气管炎后，在 11-13 岁时被诊断为哮喘的风险大约是芬兰普通人群的两倍。母亲哮喘是目前在 11-13 岁时哮喘的唯一独立的显著早期生命危险因素。
