丁丙诺啡用于新生儿戒断综合征
Buprenorphine in Neonatal Abstinence Syndrome.
作者信息
Kraft Walter K
机构信息
Sidney Kimmel Medical College of Thomas Jefferson University, Department of Pharmacology and Experimental Medicine, Philadelphia, Pennsylvania, USA.
出版信息
Clin Pharmacol Ther. 2018 Jan;103(1):112-119. doi: 10.1002/cpt.930. Epub 2017 Nov 28.
Abstract
Infants exposed in utero to opioids will demonstrate a withdrawal syndrome known as neonatal abstinence syndrome (NAS). Buprenorphine is a long-acting opioid with therapeutic use in medication-assisted treatment of opioid dependency in adults and adolescents. Emerging data from clinical trials and treatment cohorts demonstrate the efficacy and safety of sublingual buprenorphine for those infants with NAS who require pharmacologic treatment. Pharmacometric modeling will assist in defining the exposure-response relationships and facilitate dose optimization.
摘要
子宫内接触阿片类药物的婴儿会出现一种称为新生儿戒断综合征（NAS）的戒断综合征。丁丙诺啡是一种长效阿片类药物，在成人和青少年阿片类药物依赖的药物辅助治疗中具有治疗用途。来自临床试验和治疗队列的新数据表明，舌下含服丁丙诺啡对那些需要药物治疗的NAS婴儿具有疗效和安全性。药代动力学建模将有助于确定暴露-反应关系并促进剂量优化。
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