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本文引用的文献

1
Comparison of Neonatal Abstinence Syndrome Treatment with Sublingual Buprenorphine versus Conventional Opioids.舌下丁丙诺啡与传统阿片类药物治疗新生儿戒断综合征的比较
Am J Perinatol. 2018 Mar;35(4):405-412. doi: 10.1055/s-0037-1608634. Epub 2017 Nov 7.
2
Committee Opinion No. 711: Opioid Use and Opioid Use Disorder in Pregnancy.第711号委员会意见：孕期阿片类药物的使用与阿片类药物使用障碍
Obstet Gynecol. 2017 Aug;130(2):e81-e94. doi: 10.1097/AOG.0000000000002235.
3
Buprenorphine for the Treatment of the Neonatal Abstinence Syndrome.丁丙诺啡用于治疗新生儿戒断综合征
N Engl J Med. 2017 Jun 15;376(24):2341-2348. doi: 10.1056/NEJMoa1614835. Epub 2017 May 4.
4
Mortality risk during and after opioid substitution treatment: systematic review and meta-analysis of cohort studies.阿片类药物替代治疗期间及之后的死亡风险：队列研究的系统评价和荟萃分析
BMJ. 2017 Apr 26;357:j1550. doi: 10.1136/bmj.j1550.
5
Buprenorphine for managing opioid withdrawal.丁丙诺啡用于管理阿片类药物戒断。
Cochrane Database Syst Rev. 2017 Feb 21;2(2):CD002025. doi: 10.1002/14651858.CD002025.pub5.
6
Disproportionality analysis of buprenorphine transdermal system and cardiac arrhythmia using FDA and WHO postmarketing reporting system data.使用美国食品药品监督管理局（FDA）和世界卫生组织（WHO）上市后报告系统数据对丁丙诺啡透皮贴剂与心律失常进行不成比例性分析。
Postgrad Med. 2017 Jan;129(1):62-68. doi: 10.1080/00325481.2016.1271698.
7
Review: The blood-brain barrier; protecting the developing fetal brain.综述：血脑屏障；保护发育中的胎儿大脑。
Placenta. 2017 Jun;54:111-116. doi: 10.1016/j.placenta.2016.12.005. Epub 2016 Dec 6.
8
Clinical effects of unintentional pediatric buprenorphine exposures: experience at a single tertiary care center.儿童意外暴露于丁丙诺啡的临床影响：一家三级医疗中心的经验
Clin Toxicol (Phila). 2017 Jan;55(1):12-17. doi: 10.1080/15563650.2016.1244337. Epub 2016 Oct 19.
9
The Association Between Breastfeeding and Length of Hospital Stay Among Infants Diagnosed with Neonatal Abstinence Syndrome: A Population-Based Study of In-Hospital Births.母乳喂养与诊断为新生儿戒断综合征的婴儿住院时间之间的关联：一项基于人群的住院分娩研究。
Breastfeed Med. 2016 Sep;11:343-9. doi: 10.1089/bfm.2016.0084. Epub 2016 Aug 16.
10
Improving Care for Neonatal Abstinence Syndrome.改善新生儿戒断综合征的护理
Pediatrics. 2016 May;137(5). doi: 10.1542/peds.2015-3835. Epub 2016 Apr 15.

丁丙诺啡用于新生儿戒断综合征

Buprenorphine in Neonatal Abstinence Syndrome.

作者信息

Kraft Walter K

机构信息

Sidney Kimmel Medical College of Thomas Jefferson University, Department of Pharmacology and Experimental Medicine, Philadelphia, Pennsylvania, USA.

出版信息

Clin Pharmacol Ther. 2018 Jan;103(1):112-119. doi: 10.1002/cpt.930. Epub 2017 Nov 28.

DOI:10.1002/cpt.930
PMID:29105752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5739935/
Abstract

Infants exposed in utero to opioids will demonstrate a withdrawal syndrome known as neonatal abstinence syndrome (NAS). Buprenorphine is a long-acting opioid with therapeutic use in medication-assisted treatment of opioid dependency in adults and adolescents. Emerging data from clinical trials and treatment cohorts demonstrate the efficacy and safety of sublingual buprenorphine for those infants with NAS who require pharmacologic treatment. Pharmacometric modeling will assist in defining the exposure-response relationships and facilitate dose optimization.

摘要

子宫内接触阿片类药物的婴儿会出现一种称为新生儿戒断综合征（NAS）的戒断综合征。丁丙诺啡是一种长效阿片类药物，在成人和青少年阿片类药物依赖的药物辅助治疗中具有治疗用途。来自临床试验和治疗队列的新数据表明，舌下含服丁丙诺啡对那些需要药物治疗的NAS婴儿具有疗效和安全性。药代动力学建模将有助于确定暴露-反应关系并促进剂量优化。