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MedAustron轻离子束治疗设施中剂量测定设备和体模的实施。

Implementation of dosimetry equipment and phantoms at the MedAustron light ion beam therapy facility.

作者信息

Grevillot Loïc, Stock Markus, Palmans Hugo, Osorio Moreno Jhonnatan, Letellier Virgile, Dreindl Ralf, Elia Alessio, Fuchs Hermann, Carlino Antonio, Vatnitsky Stanislav

机构信息

EBG MedAustron GmbH, Marie Curie-Straße 5, A-2700, Wiener Neustadt, Austria.

National Physical Laboratory, Hampton Road, TW11 0LW, Teddington, UK.

出版信息

Med Phys. 2018 Jan;45(1):352-369. doi: 10.1002/mp.12653. Epub 2017 Nov 23.

Abstract

PURPOSE

To describe the implementation of dosimetry equipment and phantoms into clinical practice of light ion beam therapy facilities. This work covers not only standard dosimetry equipment such as computerized water scanners, films, 2D-array, thimble, and plane parallel ionization chambers, but also dosimetry equipment specifically devoted to the pencil beam scanning delivery technique such as water columns, scintillating screens or multilayer ionization chambers.

METHOD

Advanced acceptance testing procedures developed at MedAustron and complementary to the standard acceptance procedures proposed by the manufacturer are presented. Detailed commissioning plans have been implemented for each piece of dosimetry equipment and include an estimate of the overall uncertainty budget for the range of clinical use of each device. Some standard dosimetry equipment used in many facilities was evaluated in detail: for instance, the recombination of a 2D-array or the potential use of a microdiamond detector to measure reference transverse dose profiles in water in the core of the primary pencil beams and in the low-dose nuclear halo (over four orders of magnitude in dose).

RESULTS

The implementation of dosimetry equipment as described in this work allowed determining absolute spot sizes and spot positions with an uncertainty better than 0.3 mm. Absolute ranges are determined with an uncertainty comprised of 0.2-0.6 mm, depending on the measured range and were reproduced with a maximum difference of 0.3 mm over a period of 12 months using three different devices.

CONCLUSION

The detailed evaluation procedures of dosimetry equipment and phantoms proposed in this work could serve as a guidance for other medical physicists in ion beam therapy facilities and also in conventional radiation therapy.

摘要

目的

描述剂量测定设备和模体在轻离子束治疗设施临床实践中的应用。这项工作不仅涵盖了标准剂量测定设备,如计算机化水扫描器、胶片、二维阵列、指形电离室和平行板电离室,还包括专门用于笔形束扫描输送技术的剂量测定设备,如水柱、闪烁屏或多层电离室。

方法

介绍了在MedAustron开发的先进验收测试程序,这些程序是对制造商提出的标准验收程序的补充。已为每台剂量测定设备实施了详细的调试计划,其中包括对每台设备临床使用范围内总体不确定度预算的估计。对许多设施中使用的一些标准剂量测定设备进行了详细评估:例如,二维阵列的复合情况,以及使用微金刚石探测器测量初级笔形束核心区域和低剂量核晕(剂量范围超过四个数量级)水中参考横向剂量分布的潜在用途。

结果

如本文所述的剂量测定设备的应用使得能够确定绝对光斑尺寸和光斑位置,不确定度优于0.3毫米。绝对射程的确定不确定度为0.2 - 0.6毫米,具体取决于测量的射程,并且在12个月的时间内使用三种不同设备进行再现时,最大差异为0.3毫米。

结论

本文提出的剂量测定设备和模体的详细评估程序可为离子束治疗设施以及传统放射治疗中的其他医学物理师提供指导。

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