Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
DZNE, German Center for Neurodegenerative Diseases, Bonn, Germany.
Int J Methods Psychiatr Res. 2018 Mar;27(1). doi: 10.1002/mpr.1594. Epub 2017 Nov 6.
The objective of this study is to obtain population level data about cognitive functions and their association with mental disorders. We here report factor analytic and psychometric findings of a neuropsychological test battery and examine the association of current and past mental disorders with cognitive function in a large nationwide population-based sample of 18- to 79-year-old adults in Germany (n = 3,667) participating in the mental health module of the German Health Interview and Examination Survey for Adults 2008-2011. Confirmatory factor analysis confirmed verbal memory and executive function factors. Older age was strongly associated with lower verbal memory and executive function and with higher vocabulary scores. After adjustment for age, sex, and education, rather modest decrements were found for verbal memory (β = -.118, p = .002) and executive functions (β = -.191, p < .001) in participants with any current mental disorder (n = 442) compared to those without (n = 3,201). Small decrements in memory (β = -.064, p = .031) and executive function (β = -.111, p < .001) were found in participants with any mental disorder in the last 12 months but not in those with past (fully or partially remitted) mental disorders, compared to participants without a history of mental disorder. More fine-grained analyses of these data will investigate the complex interplay between cognition, health behaviors, and specific mental and somatic diseases.
本研究旨在获取认知功能及其与精神障碍相关性的人群水平数据。我们在此报告了一项神经心理学测试组合的因子分析和心理测量结果,并在德国一项大规模全国性的 18 至 79 岁成年人样本(n=3667)中,使用德国健康访谈和体检调查 2008-2011 年的心理健康模块,调查了当前和过去精神障碍与认知功能的相关性。验证性因子分析证实了言语记忆和执行功能因素。年龄较大与言语记忆和执行功能较低以及词汇得分较高有关。在调整年龄、性别和教育程度后,在任何当前精神障碍(n=442)患者中,言语记忆(β=-.118,p=.002)和执行功能(β=-.191,p<.001)的下降幅度适中,而在没有当前精神障碍的患者中(n=3201)则没有发现这种下降(β=-.064,p=.031)。在过去 12 个月中有任何精神障碍的患者中,记忆(β=-.064,p=.031)和执行功能(β=-.111,p<.001)的下降幅度较小,但在过去有(完全或部分缓解)精神障碍的患者中则没有发现这种下降,与没有精神障碍病史的患者相比。对这些数据的更精细分析将研究认知、健康行为以及特定的精神和躯体疾病之间的复杂相互作用。