German D C, Kredich N M, Bjornsson T D
Division of Rheumatology and Immunology, Duke University Medical Center, Durham, N.C.
Clin Pharmacol Ther. 1989 Jan;45(1):80-4. doi: 10.1038/clpt.1989.12.
Plasma adenosine levels in five healthy volunteers for 5 consecutive days showed far less intrasubject than intersubject variation (p less than 0.0001), indicating that plasma adenosine levels are relatively constant during this period. Plasma adenosine levels were then measured in a different group of five healthy subjects for a 5-day control period and during a 5-day course of oral dipyridamole at a dose of 100 mg every 6 hours. Intrasubject comparisons showed that plasma adenosine levels were significantly higher during the 5 days of dipyridamole administration than during the control period (p = 0.017) and that this increase was most significant after 48 hours of drug (p less than 0.001) administration. The average increase was 0.133 mumol/L (60%) with a range of 0.063 to 0.197 mumol/L (37% to 212%) during the last 3 days. A significant positive correlation was noted between plasma adenosine and dipyridamole levels (p = 0.001). We conclude that adenosine levels are relatively stable for an individual and are maximally increased after 2 days of oral dipyridamole.
连续5天对5名健康志愿者的血浆腺苷水平进行检测，结果显示个体内差异远小于个体间差异（p<0.0001），这表明在此期间血浆腺苷水平相对恒定。随后，在另一组5名健康受试者中，在为期5天的对照期以及为期5天、每6小时口服100mg双嘧达莫的疗程中测量血浆腺苷水平。个体内比较显示，双嘧达莫给药5天期间的血浆腺苷水平显著高于对照期（p=0.017），且在给药48小时后这种升高最为显著（p<0.001）。在最后3天，平均升高幅度为0.133μmol/L（60%），范围为0.063至0.197μmol/L（37%至212%）。血浆腺苷与双嘧达莫水平之间存在显著正相关（p=0.001）。我们得出结论，腺苷水平对于个体而言相对稳定，且在口服双嘧达莫2天后达到最大升高。
