情感和认知皮质纹状体通路的整合发展变化与奖励驱动的行为有关。
Developmental Changes in the Integration of Affective and Cognitive Corticostriatal Pathways are Associated with Reward-Driven Behavior.
机构信息
Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
Center for the Neural Basis of Cognition, Pittsburgh, PA, USA.
出版信息
Cereb Cortex. 2018 Aug 1;28(8):2834-2845. doi: 10.1093/cercor/bhx162.
Abstract
The relative influence of affective and cognitive processes on behavior is increasingly understood to transform through development, from adolescence into adulthood, but the neuroanatomical mechanisms underlying this change are not well understood. We analyzed diffusion magnetic resonance imaging in 115 10- to 28-year-old participants to identify convergent corticostriatal projections from cortical systems involved in affect and cognitive control and determined the age-related differences in their relative structural integrity. Results indicate that the relative integrity of affective projections, in relation to projections from cognitive control systems, decreases with age and is positively associated with reward-driven task performance. Together, these findings provide new evidence that developmental differences in the integration of corticostriatal networks involved in affect and cognitive control underlie known developmental decreases in the propensity for reward-driven behavior into adulthood.
摘要
情感和认知过程对行为的相对影响，随着个体从青少年向成年的发展，逐渐被理解为会发生转变，但这种变化的神经解剖学机制尚不清楚。我们分析了 115 名 10 至 28 岁参与者的弥散磁共振成像，以确定与情感和认知控制相关的皮质系统的会聚性皮质纹状体投射，并确定其相对结构完整性的年龄相关差异。结果表明，情感投射的相对完整性（相对于认知控制系统的投射）随年龄的增长而下降，并且与奖励驱动任务的表现呈正相关。总的来说，这些发现提供了新的证据，表明涉及情感和认知控制的皮质纹状体网络的整合在发展过程中的差异，是导致成年后奖励驱动行为倾向下降的原因。
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