基于动态预算分配的艾滋病预防数值最优控制

Numerical optimal control for HIV prevention with dynamic budget allocation.

作者信息

Gromov Dmitry, Bulla Ingo, Silvia Serea Oana, Romero-Severson Ethan O

机构信息

Faculty of Applied Mathematics and Control Processes, Saint Petersburg State University, St. Petersburg, Russia.

Institut für Mathematik und Informatik, Walther-Rathenau-Straße, Greifswald, Germany.

出版信息

Math Med Biol. 2018 Dec 5;35(4):469-491. doi: 10.1093/imammb/dqx015.

DOI:10.1093/imammb/dqx015

PMID:29106566

Abstract

This article is about numerical control of HIV propagation. The contribution of the article is threefold: first, a novel model of HIV propagation is proposed; second, the methods from numerical optimal control are successfully applied to the developed model to compute optimal control profiles; finally, the computed results are applied to the real problem yielding important and practically relevant results.

摘要

本文是关于人类免疫缺陷病毒（HIV）传播的数值控制。本文的贡献有三个方面：第一，提出了一种新的HIV传播模型；第二，将数值最优控制方法成功应用于所建立的模型，以计算最优控制曲线；最后，将计算结果应用于实际问题，得出了重要且具有实际意义的结果。