Zenz M, Strumpf M, Tryba M, Röhrs E, Steffmann B
Universitätsklinik für Anaesthesiologie, Intensiv- und Schmerztherapie, Berufsgenossenschaftliche Krankenanstalten, Bergmannsheil Bochum.
Dtsch Med Wochenschr. 1989 Jan 13;114(2):43-7. doi: 10.1055/s-2008-1066549.
35 patients with severe cancer pain received oral retard morphine. Pain reduction was achieved in each case; duration of effectiveness was between 8 and 12 hours. Mean daily dose was 230 mg morphine, but in individual cases the maximal daily dose had to be over 800 mg. The Karnofsky index of physical capacity was increased in all patients. The main side effect was constipation, which actually increased in the course of treatment. On the other hand, nausea and vomiting decreased after a few weeks. No dependence developed in any of the patients. This form of morphine medication thus was effective over long periods and it has become an important part in the range of strongly effective analgesics.
35例重度癌痛患者接受了口服缓释吗啡治疗。所有患者的疼痛均得到缓解；有效时长在8至12小时之间。吗啡的平均日剂量为230毫克，但个别病例的最大日剂量不得不超过800毫克。所有患者的卡氏体能指数均有所提高。主要副作用是便秘，实际上在治疗过程中便秘情况还加重了。另一方面，几周后恶心和呕吐症状减轻。所有患者均未产生依赖性。因此，这种吗啡给药方式长期有效，已成为强效镇痛药中的重要组成部分。
