Sen Selda, Aydin Osman N, Aydin Kutlay
Department of Anesthesiology and Reanimation, State Hospital Anesthesiology and Reanimation Clinic, Adnan Menderes University, Medical Faculty, Aydin, Turkey.
Pain Med. 2006 Mar-Apr;7(2):166-9. doi: 10.1111/j.1526-4637.2006.00111.x.
Two patients experiencing cancer pain with neuropathic components were treated with epidural administration of a mixture of ketamine (1 mg/mL) + morphine (1 mg/mL) + bupivacaine (1 mg/mL) injected daily by epidural port. No serious adverse effect was observed throughout the therapy. The patients were mostly pain-free and have gotten better quality of life during 110- and 48-day follow-up when the therapy was given by epidural route. Low doses of epidural ketamine added to morphine and bupivacaine increase the mean duration of satisfactory analgesia without severe adverse effects and restore quality of life when traditional therapy fails.
两名患有伴有神经病理性成分的癌痛患者，通过硬膜外端口每日注射氯胺酮（1毫克/毫升）+吗啡（1毫克/毫升）+布比卡因（1毫克/毫升）的混合物进行硬膜外给药治疗。整个治疗过程中未观察到严重不良反应。在通过硬膜外途径进行治疗后的110天和48天随访期间，患者大多无痛，生活质量得到改善。当传统治疗无效时，低剂量硬膜外氯胺酮联合吗啡和布比卡因可延长满意镇痛的平均持续时间，且无严重不良反应，并能恢复生活质量。
