全身总病变糖酵解是接受根治性放化疗的食管癌患者的独立预测因子。
Whole-body total lesion glycolysis is an independent predictor in patients with esophageal cancer treated with definitive chemoradiotherapy.
机构信息
Department of Radiation Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Department of Radiation Oncology, Tohoku University Graduate School of Medicine, Sendai, Japan.
出版信息
Radiother Oncol. 2018 Oct;129(1):161-165. doi: 10.1016/j.radonc.2017.10.019. Epub 2017 Nov 3.
BACKGROUND AND PURPOSE
To determine whether pretreatment whole-body total lesion glycolysis (TLG) and metabolic tumor volume (MTV) are associated with outcomes in patients with esophageal cancer treated with definitive chemoradiotherapy (dCRT).
MATERIALS AND METHODS
Ninety patients with stage II or III thoracic esophageal cancer who underwent FDG-PET/CT within 45 days before dCRT between 2005 and 2013 were reviewed. MTV and TLG of the primary lesion (MTV and TLG) and the sum of MTV and TLG for all lesions (MTV and TLG) were calculated. Predictors were analyzed using the Cox proportional hazards model.
RESULTS
The median follow-up period was 27.7 months. In multivariate analysis, MTV > median was an unfavorable predictor for OS (p = 0.027, hazard ratio [HR]: 2.15), LC (p = 0.039, HR: 1.98) and PFS (p = 0.041, HR: 1.96). TLG > median was an unfavorable predictor for OS (p = 0.019, HR: 2.26), LC (p = 0.015, HR: 2.36) and PFS (p = 0.014, HR: 2.33). SUV was not a predictor, and the HR of TLG was higher than that of MTV for OS, LC and PFS in multivariate analysis.
CONCLUSION
TLG and MTV are independent predictors in patients with esophageal cancer.
背景与目的
旨在确定在接受根治性放化疗（dCRT）的食管癌患者中，治疗前全身总病变糖酵解（TLG）和代谢肿瘤体积（MTV）是否与结局相关。
材料与方法
回顾了 2005 年至 2013 年间 90 例在 dCRT 前 45 天内行 FDG-PET/CT 的 II 期或 III 期胸段食管癌患者。计算了原发肿瘤的 MTV 和 TLG（MTV 和 TLG）以及所有病变的 MTV 和 TLG 之和（MTV 和 TLG）。使用 Cox 比例风险模型分析预测因素。
结果
中位随访时间为 27.7 个月。多变量分析中，MTV＞中位数是 OS（p=0.027，风险比 [HR]：2.15）、LC（p=0.039，HR：1.98）和 PFS（p=0.041，HR：1.96）不良预后的预测因素。TLG＞中位数是 OS（p=0.019，HR：2.26）、LC（p=0.015，HR：2.36）和 PFS（p=0.014，HR：2.33）不良预后的预测因素。SUV 不是预测因素，并且在多变量分析中，TLG 的 HR 高于 MTV 对于 OS、LC 和 PFS。
结论
TLG 和 MTV 是食管癌患者的独立预测因素。
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