终末期肾病在治疗糖尿病酮症酸中毒或高渗高血糖状态时会增加不良血糖事件的发生率。
End-Stage Renal Disease Increases Rates of Adverse Glucose Events When Treating Diabetic Ketoacidosis or Hyperosmolar Hyperglycemic State.
作者信息
Schaapveld-Davis Caitlin M, Negrete Ana L, Hudson Joanna Q, Saikumar Jagannath, Finch Christopher K, Kocak Mehmet, Hu Pan, Van Berkel Megan A
机构信息
Methodist University Hospital, Memphis, TN.
University of Tennessee Health and Science Center College of Pharmacy, Memphis, TN.
出版信息
Clin Diabetes. 2017 Oct;35(4):202-208. doi: 10.2337/cd16-0060.
Abstract
Treatment guidelines for diabetic emergencies are well described in patients with normal to moderately impaired kidney function. However, management of patients with end-stage renal disease (ESRD) is an ongoing challenge. This article describes a retrospective study comparing the rates of adverse glucose events (defined as hypoglycemia or a decrease in glucose >200 mg/dL/h) between patients with ESRD and those with normal kidney function who were admitted with diabetic ketoacidosis (DKA) or hyperosmolar hyperglycemic state (HHS). These results indicate that current treatment approaches to DKA or HHS in patients with ESRD are suboptimal and require further evaluation.
摘要
糖尿病急症的治疗指南在肾功能正常至中度受损的患者中已有详尽描述。然而，终末期肾病（ESRD）患者的管理仍是一项持续存在的挑战。本文描述了一项回顾性研究，比较了因糖尿病酮症酸中毒（DKA）或高渗高血糖状态（HHS）入院的ESRD患者与肾功能正常患者之间不良血糖事件（定义为低血糖或血糖每小时下降>200mg/dL）的发生率。这些结果表明，目前针对ESRD患者DKA或HHS的治疗方法并不理想，需要进一步评估。
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