Li Yuan, Ding Wen-Xing
Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS, USA.
Liver Res. 2017 Jun;1(1):54-62. doi: 10.1016/j.livres.2017.03.004. Epub 2017 Apr 26.
Alcohol consumption leads to injury in multiple organs and systems, including the liver, brain, heart, skeletal muscle, pancreas, bone, immune system, and endocrine system. Emerging evidence indicates that alcohol also promotes adipose tissue dysfunction, which may contribute to injury progression in other organs and systems. Autophagy is a lysosomal degradation pathway that has been shown to regulate adipose tissue homeostasis and adipogenesis. Increasing evidence also demonstrates that alcohol consumption affects autophagy in multiple tissues. This review summarizes current knowledge regarding the effect of autophagy on adipose tissue and its potential roles in alcohol-induced adipose tissue atrophy as well as its contribution to alcohol-induced liver injury.
饮酒会导致多个器官和系统受损，包括肝脏、大脑、心脏、骨骼肌、胰腺、骨骼、免疫系统和内分泌系统。新出现的证据表明，酒精还会促进脂肪组织功能障碍，这可能会导致其他器官和系统的损伤进展。自噬是一种溶酶体降解途径，已被证明可调节脂肪组织的稳态和脂肪生成。越来越多的证据也表明，饮酒会影响多个组织中的自噬。本综述总结了关于自噬对脂肪组织的影响及其在酒精性脂肪组织萎缩中的潜在作用以及对酒精性肝损伤的贡献的现有知识。
