Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160, USA.
Department of Pathology, Division of Molecular Cellular Pathology, University of Alabama at Birmingham, 901 19th street South, Birmingham, AL 35294, USA.
Cells. 2020 Mar 31;9(4):837. doi: 10.3390/cells9040837.
The mitochondrion is an organelle that plays a vital role in the regulation of hepatic cellular redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both acute and chronic liver diseases with emerging evidence indicating that mitophagy, a selective form of autophagy for damaged/excessive mitochondria, plays a key role in the liver's physiology and pathophysiology. This review will focus on mitochondrial dynamics, mitophagy regulation, and their roles in various liver diseases (alcoholic liver disease, non-alcoholic fatty liver disease, drug-induced liver injury, hepatic ischemia-reperfusion injury, viral hepatitis, and cancer) with the hope that a better understanding of the molecular events and signaling pathways in mitophagy regulation will help identify promising targets for the future treatment of liver diseases.
线粒体是一种在调节肝脏细胞氧化还原、脂质代谢和细胞死亡方面起着至关重要作用的细胞器。线粒体功能障碍与急性和慢性肝病有关，越来越多的证据表明，自噬是一种选择性清除损伤/过度线粒体的自噬形式，在肝脏的生理和病理生理学中起着关键作用。本文综述了线粒体动力学、自噬调节及其在各种肝脏疾病（酒精性肝病、非酒精性脂肪性肝病、药物性肝损伤、肝缺血再灌注损伤、病毒性肝炎和肝癌）中的作用，希望更好地了解自噬调节中的分子事件和信号通路，有助于为未来治疗肝脏疾病确定有前途的靶点。
