Elias M F, Schultz N R, Robbins M A, Elias P K
Department of Psychology, University of Maine.
J Gerontol. 1989 Jan;44(1):P25-8. doi: 10.1093/geronj/44.1.p25.
The neuropsychological test performance of hypertensive and normotensive subjects was compared at three times of measurement over a 10-year period. The tests used were among those that are most sensitive to brain impairment in the Halstead-Reitan battery. In addition to individual test measures, a widely used clinical index of battery-wide performance--the Average Impairment Rating (AIR)--was used. Hypertensives exhibited lower mean levels of performance on the AIR at all times of measurement. However, the Blood Pressure Group x Time of Measurement interactions were not statistically significant, indicating that hypertensives and normotensives did not exhibit a differential rate of change (decline or improvement) over time. Hypertensives also performed more poorly for a measure of learning set formation (categories test) and two tests of memory for forms experienced by touch only (tactile perception memory and localization tests). However, Blood Pressure x Time of Measurement interactions were not observed for these measures.
在10年期间的三个测量时间点，对高血压患者和血压正常者的神经心理学测试表现进行了比较。所使用的测试来自于那些对Halstead - Reitan成套神经心理测验中对脑损伤最敏感的测试。除了个别测试指标外，还使用了一个广泛应用的反映整个成套测试表现的临床指标——平均损伤评分（AIR）。在所有测量时间点，高血压患者的AIR平均表现水平较低。然而，血压组×测量时间的交互作用在统计学上并不显著，这表明高血压患者和血压正常者在随时间推移并没有表现出不同的变化率（下降或改善）。高血压患者在学习集形成测量（分类测试）以及仅通过触摸体验的两种形式记忆测试（触觉感知记忆和定位测试）中表现也更差。然而，这些测量指标未观察到血压×测量时间的交互作用。
