Elias P K, D'Agostino R B, Elias M F, Wolf P A
Department of Mathematics, Boston University, MA 02215, USA.
Exp Aging Res. 1995 Oct-Dec;21(4):393-417. doi: 10.1080/03610739508253992.
The relationships of three blood pressure variables (systolic and diastolic pressures and chronicity of hypertension) and age to cognitive performance on the Kaplan-Albert Neuropsychological Test Battery were explored in a sample of 1,695 stroke-free participants of the Framingham Heart Study. Multiple blood pressure measurements were obtained over four or five exams extending over 8-10 years. Neuropsychological testing was conducted 12-14 years after the final blood pressure measurement. Data were subject to multiple binary logistic regression analyses, and odds ratios were calculated for performance in the lower 50th and 25th percentiles for 10-mmHg increases in diastolic blood pressure, 20-mmHg increases in systolic blood pressure, proportion of exams (out of four or five) in which participants were diagnosed as hypertensive, and 10-year increases in age. Blood pressures and chronicity of hypertension were inversely associated with performance on visual and verbal memory tests of the Kaplan-Albert battery. Age was inversely associated with performance on all tests in the battery. Generally, the odds of performing poorly were higher for age than for the blood pressure variables. The epidemiological significance of these findings is discussed in terms of implications for public health and management of hypertension.
在弗明汉心脏研究的1695名无中风参与者样本中，探讨了三个血压变量（收缩压和舒张压以及高血压的病程）和年龄与卡普兰 - 阿尔伯特神经心理测试组认知表现之间的关系。在8至10年期间进行的四或五次检查中获取了多次血压测量值。在最后一次血压测量后的12至14年进行神经心理测试。数据进行了多次二元逻辑回归分析，并计算了舒张压每升高10mmHg、收缩压每升高20mmHg、参与者被诊断为高血压的检查比例（四或五次检查中）以及年龄每增加10岁时，处于第50百分位数和第25百分位数以下表现的优势比。血压和高血压病程与卡普兰 - 阿尔伯特测试组的视觉和言语记忆测试表现呈负相关。年龄与测试组中的所有测试表现呈负相关。一般来说，年龄导致表现不佳的几率高于血压变量。从对公共卫生和高血压管理的影响方面讨论了这些发现的流行病学意义。
