López-López José R, Cidad Pilar, Pérez-García M Teresa
Departamento de Bioquímica y Biología Molecular y Fisiología e Instituto de Biología y Genética Molecular (IBGM), Universidad de Valladolid y Consejo Superior de Investigaciones Científicas (CSIC), Valladolid, Spain.
Microcirculation. 2018 Jan;25(1). doi: 10.1111/micc.12427.
Kv channels are present in virtually all VSMCs and strongly influence contractile responses. However, they are also instrumental in the proliferative, migratory, and secretory functions of synthetic, dedifferentiated VSMCs upon PM. In fact, Kv channels not only contribute to all these processes but also are active players in the phenotypic switch itself. This review is focused on the role(s) of Kv channels in VSMC proliferation, which is one of the best characterized functions of dedifferentiated VSMCs. VSMC proliferation is a complex process requiring specific Kv channels at specific time and locations. Their identification is further complicated by their large diversity and the differences in expression across vascular beds. Of interest, both conserved changes in some Kv channels and vascular bed-specific regulation of others seem to coexist and participate in VSMC proliferation through complementary mechanisms. Such a system will add flexibility to the process while providing the required robustness to preserve this fundamental cellular response.
钾离子通道几乎存在于所有血管平滑肌细胞中，并对收缩反应有强烈影响。然而，它们在合成的、去分化的血管平滑肌细胞受到血小板衍生生长因子刺激后的增殖、迁移和分泌功能中也发挥着重要作用。事实上，钾离子通道不仅参与所有这些过程，而且在表型转换本身中也是活跃的参与者。本综述聚焦于钾离子通道在血管平滑肌细胞增殖中的作用，这是去分化血管平滑肌细胞最具特征的功能之一。血管平滑肌细胞增殖是一个复杂的过程，在特定的时间和位置需要特定的钾离子通道。由于它们的多样性以及不同血管床中表达的差异，对它们的识别进一步复杂化。有趣的是，一些钾离子通道的保守变化和其他通道的血管床特异性调节似乎并存，并通过互补机制参与血管平滑肌细胞增殖。这样一个系统将为这一过程增加灵活性，同时提供所需的稳健性以维持这种基本的细胞反应。
