Qiu Wen-Ying, Yang Qian, Zhang Wanying, Wang Naili, Zhang Di, Huang Yue, Ma Chao
Department of Human Anatomy, Histology and Embryology, Institute of Basic Medical Sciences, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China.
Brain Bank at China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, 100050, China.
Curr Alzheimer Res. 2018 Mar 14;15(5):462-473. doi: 10.2174/1567205014666171106150915.
The pathological diagnostic criteria for Alzheimer's disease (AD) updated by the National Institute on Aging-Alzheimer's Association (NIA-AA) in 2012 has been widely adopted, but the clinicopathological relevance remained obscure in Chinese population.
This study aims to investigate the correlations between the antemortem clinical cognitive performances and the postmortem neuropathological changes in the aging and AD brains collected in a human brain bank in China.
A total of 52 human brains with antemortem cognitive status information [Everyday Cognition (ECog)] were collected through the willed donation program by CAMS/PUMC Human Brain Bank. Pathological changes were evaluated with the "ABC" score following the guidelines of NIA-AA. The clinicopathological relationship was analyzed with correlation analysis and general linear multivariate model.
The general ABC score has a significant correlation with global ECog score (r=0.37, p=0.014) and most of ECog domains. The CERAD score of neuritic plaques (C score) has a significant correlation with global ECog score (r=0.40, p=0.007) and the majority of ECog domains, such as memory (r=0.50, p=0.001), language (r=0.45, p=0.002), visuospatial functions (r=0.31, p=0.040), planning (r=0.35, p=0.021) and organization (r=0.39, p=0.010). The Braak stage of neurofibrillary tangles (NFTs) (B score) has a moderate correlation with memory (r=0.32, p=0.035). The Thal phases of amyloid-β (Aβ) deposits (A score) present no significant correlation with any of ECog domains.
In this study, we verified the correlation of postmortem C and B scores, but not the A score with cognition performance in a collection of samples from the Chinese human brain bank.
美国国立衰老研究所-阿尔茨海默病协会（NIA-AA）于2012年更新的阿尔茨海默病（AD）病理诊断标准已被广泛采用，但在中国人群中临床病理相关性仍不明确。
本研究旨在调查中国一家人类脑库中收集的衰老及AD大脑生前临床认知表现与死后神经病理变化之间的相关性。
通过中国医学科学院/北京协和医学院人类脑库的自愿捐赠项目，共收集了52例具有生前认知状态信息[日常认知（ECog）]的人类大脑。按照NIA-AA指南，采用“ABC”评分评估病理变化。采用相关性分析和一般线性多变量模型分析临床病理关系。
总体ABC评分与总体ECog评分（r=0.37，p=0.014）及大多数ECog领域显著相关。神经炎性斑块的CERAD评分（C评分）与总体ECog评分（r=0.40，p=0.007）及大多数ECog领域显著相关，如记忆（r=0.50，p=0.001）、语言（r=0.45，p=0.002）、视觉空间功能（r=0.31，p=0.040）、计划（r=0.35，p=0.021）和组织（r=0.39，p=0.010）。神经原纤维缠结（NFTs）的Braak分期（B评分）与记忆呈中度相关（r=0.32，p=0.035）。淀粉样β蛋白（Aβ）沉积的Thal分期（A评分）与任何ECog领域均无显著相关性。
在本研究中，我们在中国人类脑库的样本集中验证了死后C评分和B评分与认知表现的相关性，但未验证A评分与认知表现的相关性。
