Kidney Health Research Collaborative, Department of Medicine, University of California San Francisco, San Francisco, CA; Department of Medicine, San Francisco VA Medical Center, San Francisco, CA.
Division of Nephrology, Departments of Pediatrics and Medicine, The Hospital for Sick Children, SickKids Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Semin Nephrol. 2017 Nov;37(6):520-529. doi: 10.1016/j.semnephrol.2017.07.005.
Variants of the APOL1 gene, found primarily in individuals of African descent, are associated with various forms of kidney disease and kidney disease progression. Recent studies evaluating the association of APOL1 with cardiovascular disease have yielded conflicting results, and the potential role in cardiovascular disease remains unclear. In this review, we summarize the observational studies linking the APOL1 risk variants with chronic kidney and cardiovascular disease among persons of African descent.
APOL1 基因的变体主要存在于非洲裔个体中，与各种形式的肾脏疾病和肾脏疾病进展有关。最近评估 APOL1 与心血管疾病相关性的研究结果相互矛盾，其在心血管疾病中的潜在作用仍不清楚。在这篇综述中，我们总结了将 APOL1 风险变体与非洲裔人群的慢性肾脏病和心血管疾病联系起来的观察性研究。
