Wester Tomas, Granström Anna Löf
Department of Pediatric Surgery, Karolinska University Hospital, Stockholm, Sweden; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Department of Pediatric Surgery, Karolinska University Hospital, Stockholm, Sweden; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Semin Pediatr Surg. 2017 Oct;26(5):322-327. doi: 10.1053/j.sempedsurg.2017.09.008. Epub 2017 Sep 9.
Hirschsprung disease is a developmental defect of the enteric nervous system characterized by lack of enteric neurons in the distal hindgut. There are numerous reports on short-term outcomes indicating that impaired bowel function is common. Recently, several controlled studies show that bowel function outcomes are affected beyond childhood, in adolescents and adults, compared with healthy control subjects. Constipation and fecal incontinence are common. The impaired bowel function appears to have a negative impact on quality of life, although, a majority of patients have adapted to their symptoms. On the other hand, Hirschsprung disease seems to have limited impact on education and occupation in adult life. The aim of this review was to summarize current knowledge of bowel function outcome beyond childhood in patients with Hirschsprung disease.
先天性巨结肠是一种肠道神经系统的发育缺陷，其特征是后肠远端缺乏肠神经元。有许多关于短期结果的报告表明，肠道功能受损很常见。最近，几项对照研究表明，与健康对照受试者相比，青少年和成年人的肠道功能结果在儿童期之后仍受到影响。便秘和大便失禁很常见。尽管大多数患者已经适应了他们的症状，但肠道功能受损似乎对生活质量有负面影响。另一方面，先天性巨结肠似乎对成年后的教育和职业影响有限。本综述的目的是总结先天性巨结肠患者儿童期之后肠道功能结果的现有知识。
