School of Sport, Exercise and Health Sciences, National Centre for Sport & Exercise Medicine - East Midlands, Loughborough University, Loughborough LE11 3TU, United Kingdom.
School of Sport, Exercise and Health Sciences, National Centre for Sport & Exercise Medicine - East Midlands, Loughborough University, Loughborough LE11 3TU, United Kingdom.
Prev Med. 2018 Jan;106:145-149. doi: 10.1016/j.ypmed.2017.10.030. Epub 2017 Oct 28.
The longitudinal association between physical activity and lung function is unclear. Therefore, we examined said association over eight years. This study included data from 2966 participants in English Longitudinal Study of Ageing (63±7years [mean±SD]), a prospective study of initially healthy, community dwelling adults. Physical activity was assessed using an interview and lung function using a spirometer at baseline (2004-5) and follow-up (2012-13). General linear regression was used to assess associations between activity and lung function. Logistic regression was used to assess the odds of new cases of abnormal lung function. Some 14% of participants were defined as physically inactive at baseline, 50% were classified into the moderate group, and 36% into the vigorous group. In comparison with remaining inactive at follow-up, remaining active was positively associated with forced vital capacity (FVC) (β=0.09, 95% confidence interval [CI]: 0.01, 0.17; p=0.02) and forced expiratory volume in one second (FEV-1) (β=0.09, 95% CI: 0.02, 0.15; p=0.01) after adjustment for baseline lung function score and other covariates. Using the fifth centile to define the lower limit of normal (that is, -1.64 z scores), there were lower odds of incident abnormal lung function in participants who remained physically active compared to those who remained inactive (FVC odds ratio=0.31, 95% CI: 0.17, 0.55. FEV-1 odds ratio=0.43, 95% CI: 0.26, 0.72). Similar associations were observed in those who became active. This study suggests that remaining physically active or becoming active in older age is positively associated with lung function and reduced odds of abnormal lung function.
体力活动与肺功能之间的纵向关联尚不清楚。因此，我们在八年的时间里对此关联进行了研究。这项研究纳入了英国老龄化纵向研究（年龄 63±7 岁[均值±标准差]）中的 2966 名参与者的数据，该研究是一项针对最初健康的社区居住成年人的前瞻性研究。在基线（2004-5 年）和随访（2012-13 年）时，使用访谈评估体力活动，使用肺活量计评估肺功能。使用一般线性回归评估活动与肺功能之间的关联。使用逻辑回归评估新出现的异常肺功能病例的几率。在基线时，约 14%的参与者被定义为体力活动不足，50%的参与者被归类为中度组，36%的参与者被归类为剧烈组。与随访时仍保持不活动相比，保持活跃与用力肺活量（FVC）（β=0.09，95%置信区间[CI]：0.01，0.17；p=0.02）和一秒用力呼气量（FEV-1）（β=0.09，95% CI：0.02，0.15；p=0.01）呈正相关，校正基线肺功能评分和其他协变量后。使用第五百分位数来定义正常下限（即-1.64 z 分数），与仍不活跃的参与者相比，保持身体活跃的参与者发生异常肺功能的几率较低（FVC 比值比=0.31，95% CI：0.17，0.55。FEV-1 比值比=0.43，95% CI：0.26，0.72）。在新开始活跃的参与者中也观察到类似的关联。这项研究表明，在老年时保持身体活跃或开始活跃与肺功能呈正相关，并降低异常肺功能的几率。
