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急性早幼粒细胞白血病中出现的糙面内质网相关管状结构。

Rough endoplasmic reticulum-associated tubular structures occurring in acute promyelocytic leukaemia.

作者信息

Tange T, Chiba S

出版信息

Scand J Haematol. 1979 Jul;23(1):25-9. doi: 10.1111/j.1600-0609.1979.tb02848.x.

DOI:10.1111/j.1600-0609.1979.tb02848.x
PMID:291118
Abstract

Intracytoplasmic tubular structures (TS) which have not yet been described were found electron microscopically in a large percentage (26.5%) of leukaemic cells from a 25-year-old female with acute promyelocytic leukaemia. The TS were bundles of tubules measuring about 90 nm in diameter and continuous with rough endoplasmic reticulum, the maximum of the TS attaining 3.0 micron in length and 0.53 micron in width. The TS were mostly solitary, occasionally 2 or 3 within a cell in a plane of sectioning and were usually located around the Golgi region. By three-dimensional observation with a goniometer stage, it was confirmed that the TS showed latticework of rings in cross sections and fascicular tubular arrays in longitudinal sections. In the latter, some tubules exhibited meshworks of polygonal vesicles measuring about 20 nm and cross striations of filamentous bristles with the periodicity of about 22 nm. The origin and nature of the TS are discussed.

摘要

在一名25岁急性早幼粒细胞白血病女性患者的大量白血病细胞(占26.5%)中,通过电子显微镜发现了尚未见报道的胞质内管状结构(TS)。TS是直径约90nm的小管束,与粗面内质网相连,TS最长可达3.0微米,最宽处为0.53微米。TS大多单个存在,在切片平面上一个细胞内偶尔有2个或3个,通常位于高尔基体区域周围。通过测角台进行三维观察证实,TS在横切面上呈环状网格状,在纵切面上呈束状管状排列。在纵切面上,一些小管呈现出直径约20nm的多边形囊泡网状结构以及周期约为22nm的丝状刷毛样横纹。文中对TS的起源和性质进行了讨论。

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