Parkin J L, Brunning R D
Ultrastruct Pathol. 1980 Jan-Mar;1(1):55-65. doi: 10.3109/01913128009141395.
The leukemic cells from 9 patients with acute myelogenous leukemia were studied by light microscopy, cytochemistry, and electron microscopy. In Wright-Giemsa-stained blood and bone marrow preparations, from less than 1% to greater than 95% of the leukemic cells from the 9 patients contained inclusions that measured one-third to one-half the diameter of the cell. In 4 patients the inclusions appeared to be associated with intense focal myeloperoxidase activity. Ultrastructural studies demonstrated that the inclusions were complexes of smooth, membranous, anastomosing 50-nm tubules and 80-nm particles. These complexes were surrounded by bundles of microfilaments and numerous mitochondria. The tubular complexes resembled the tubuloreticular structures that have been reported in lymphoreticular and endothelial cells from patients with autoimmune and viral diseases.
对9例急性髓性白血病患者的白血病细胞进行了光学显微镜、细胞化学和电子显微镜研究。在瑞氏-吉姆萨染色的血液和骨髓涂片上，9例患者中不到1%至超过95%的白血病细胞含有直径为细胞直径三分之一至二分之一的包涵体。在4例患者中，这些包涵体似乎与强烈的局灶性髓过氧化物酶活性有关。超微结构研究表明，这些包涵体是由光滑的、膜性的、相互吻合的50纳米小管和80纳米颗粒组成的复合体。这些复合体被微丝束和大量线粒体包围。这些管状复合体类似于在自身免疫性疾病和病毒性疾病患者的淋巴网状细胞和内皮细胞中所报道的管状网状结构。
