Martini Silvia, Aceti Arianna, Beghetti Isadora, Faldella Giacomo, Corvaglia Luigi
Neonatology and Neonatal Intensive Care Unit, Department of Medical and Surgical Sciences (DIMEC), St Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
J Pediatr Gastroenterol Nutr. 2018 May;66(5):755-759. doi: 10.1097/MPG.0000000000001804.
Preterm infants with antenatal absent or reversed end diastolic flow (AREDF) in umbilical arteries are at major risk for gastrointestinal (GI) complications, such as necrotizing enterocolitis, intestinal perforation and feeding intolerance. Near-infrared spectroscopy provides continuous monitoring of splanchnic oxygenation (SrSO2) and may represent a useful tool to predict GI outcomes in this high-risk population. This observational, pilot study assessed feed-related SrSO2 patterns at enteral feeding introduction and full enteral feeding (FEF) achievement in twenty AREDF infants with gestational age ≤34 weeks. Enrolled infants were divided into 2 groups according to the development versus lack of GI complications. Infants developing GI complications showed significantly lower SrSO2 and increased splanchnic oxygen extraction in response to enteral feeds at both enteral feeding introduction and FEF. The potential role of these findings in predicting GI complications in AREDF preterm infants seems promising and deserves further evaluation.
脐动脉产前舒张末期血流缺失或反向（AREDF）的早产儿发生胃肠道（GI）并发症的风险很高，如坏死性小肠结肠炎、肠穿孔和喂养不耐受。近红外光谱可连续监测内脏氧合（SrSO2），可能是预测这一高危人群胃肠道结局的有用工具。这项观察性试点研究评估了20例胎龄≤34周的AREDF婴儿在开始肠内喂养和实现完全肠内喂养（FEF）时与喂养相关的SrSO2模式。根据是否发生胃肠道并发症，将纳入的婴儿分为两组。发生胃肠道并发症的婴儿在开始肠内喂养和FEF时，对肠内喂养的反应显示SrSO2显著降低，内脏氧摄取增加。这些发现对预测AREDF早产儿胃肠道并发症的潜在作用似乎很有前景，值得进一步评估。
