用于谷胱甘肽S-转移酶和缺氧诱导因子-1α抑制的双靶点癌症诊疗试剂
Dual-target cancer theranostic for glutathione S-transferase and hypoxia-inducible factor-1α inhibition.
作者信息
Li Zan, Ding Jie, Chen Chunxia, Chang Jiayin, Huang Binghuan, Geng Zhirong, Wang Zhilin
机构信息
State key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093, P. R. China.
出版信息
Chem Commun (Camb). 2017 Nov 16;53(92):12406-12409. doi: 10.1039/c7cc08162f.
We developed a dual-target theranostic F, which could exhibit synergetic anticancer effects for inhibiting the activities of glutathione S-transferase and the accumulation of hypoxia inducible factor-1α. F undergoes self-immolative cleavage when exposed to GSTP1-1 in live cancer cells, facilitating the visualization of molecule release and distribution, as well as confirming the autophagy-induced apoptosis.
我们开发了一种双靶点诊疗试剂F，它在抑制谷胱甘肽S-转移酶活性和缺氧诱导因子-1α积累方面可展现协同抗癌效果。F在活癌细胞中暴露于GSTP1-1时会发生自裂解，有助于分子释放和分布的可视化，以及确认自噬诱导的细胞凋亡。
Zotero 插件