Min Guang-Tao, Li Yu-Min, Yao Nan, Wang Jun, Wang Hong-Peng, Chen Wei
Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China.
The First Clinical Medical College of Lanzhou University, Lanzhou, China.
Clin Transplant. 2018 Jan;32(1). doi: 10.1111/ctr.13151. Epub 2017 Dec 4.
At present, several studies have reported that the pretreatment neutrophil-lymphocyte ratio (NLR) may be associated with the prognosis of liver cancer. Nevertheless, their conclusions remain controversial. Thus, we performed a meta-analysis of 54 studies to evaluate the prognostic value of NLR.
Databases including PubMed, Embase, Cochrane Library, and Web of Science were searched to July 2017.
A total of 54 studies including 12 979 patients were included in this meta-analysis. Elevated NLR had a close relationship with the overall survival (OS) (HR 1.52; 95% CI 1.39-1.67), recurrence-free survival (RFS) (HR 1.84; 95% CI 1.48-2.30), and disease-free survival (DFS) (HR 1.71; 95% CI 1.39-2.11) of liver cancer, respectively. In addition, elevated NLR was associated with the presence of tumor vascular invasion (OR 2.35; 95% CI 1.93-2.86), multiple tumors (OR 1.38; 95% CI 1.15-1.66), alpha-fetoprotein ≥ 400 ng/mL (OR 1.51; 95% CI 1.15-1.98), presence of HbsAg (+) (OR 0.68; 95% CI 0.51-0.90), and cirrhosis (OR: 0.59; 95% CI 0.44-0.80).
This meta-analysis indicated that elevated NLR may be an effective and noninvasive indicator for prognosis of patients with liver cancer.
目前，多项研究报道，治疗前中性粒细胞与淋巴细胞比值（NLR）可能与肝癌预后相关。然而，其结论仍存在争议。因此，我们对54项研究进行了荟萃分析，以评估NLR的预后价值。
检索截至2017年7月的数据库，包括PubMed、Embase、Cochrane图书馆和Web of Science。
本荟萃分析共纳入54项研究，涉及12979例患者。NLR升高分别与肝癌的总生存期（OS）（风险比1.52；95%置信区间1.39 - 1.67）、无复发生存期（RFS）（风险比1.84；95%置信区间1.48 - 2.30）和无病生存期（DFS）（风险比1.71；95%置信区间1.39 - 2.11）密切相关。此外，NLR升高与肿瘤血管侵犯的存在（比值比2.35；95%置信区间1.93 - 2.86）、多发肿瘤（比值比1.38；95%置信区间1.15 - 1.66）、甲胎蛋白≥400 ng/mL（比值比1.51；95%置信区间1.15 - 1.98）、乙肝表面抗原（+）的存在（比值比0.68；95%置信区间0.51 - 0.90）以及肝硬化（比值比：0.59；95%置信区间0.44 - （此处原文有误，应为0.79）0.80）相关。
本荟萃分析表明，NLR升高可能是肝癌患者预后的一种有效且无创的指标。 （最后一句中原文95% CI 0.44 - 0.80有误，根据逻辑推测应为0.44 - 0.79，译文已修正）
