过渡金属非立体选择性二醇与硼酸作为亲核试剂的交叉偶联反应。
Transition-Metal-Free Stereocomplementary Cross-Coupling of Diols with Boronic Acids as Nucleophiles.
机构信息
Instituto Pluridisciplinar, Universidad Complutense, Campus de Excelencia Internacional Moncloa , Paseo de Juan XXIII, 1, 28040 Madrid, Spain.
出版信息
Org Lett. 2017 Nov 17;19(22):6236-6239. doi: 10.1021/acs.orglett.7b03192. Epub 2017 Nov 7.
The transition-metal-free diastereoselective C(sp)-C(sp) cross-coupling between unprotected diols and boronic acids or potassium organotrifluoroborates is reported. Depending on the reaction conditions, the syn or the anti reaction products are obtained in a stereocomplementary fashion. This type of coupling is developed with alkenyl-, heteroaryl- and arylboron compounds as carbon nucleophiles.
本文报道了一种无过渡金属的非对映选择性 C(sp)-C(sp) 交叉偶联反应，该反应在保护的二醇和硼酸或有机三氟硼酸钾之间进行。根据反应条件的不同，可以以立体互补的方式得到顺式或反式反应产物。这种偶联反应使用烯基、杂芳基和芳基硼化合物作为碳亲核试剂进行。
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