Buonomo Antonio Riccardo, Scotto Riccardo, Pinchera Biagio, Coppola Nicola, Monari Caterina, Macera Margherita, Borgia Guglielmo, Gentile Ivan
Department of Clinical Medicine and Surgery, Section of Infectious Diseases. University of Naples "Federico II", Italy.
Department of Mental Health and Public Medicine, Infectious Disease Unit.University of Campania Luigi Vanvitelli.
New Microbiol. 2018 Jan;41(1):26-29. Epub 2017 Nov 7.
Hepatitis C virus (HCV) is globally widespread. Southern Italy is a high prevalence region where the distribution of the HCV genotypes (GTs) is changing. Intravenous drug abuse is the only risk factor associated with a specific HCV GT (GT3). The aim of this study was to evaluate the distribution and the risk factors for specific HCV GTs. A total of 682 patients with measurable serum HCV-RNA were enrolled between January and March 2017. We recorded clinical information and the presence of risk factors for HCV. GT1b was the prevalent genotype in our patients (59.8%). HCV GT1a and GT3 infections were more frequent among patients aged ≤60 years (14.9% vs 2.2%, p<0.01 and 13.6% vs 0.8%, p<0.01, respectively). At multivariate analysis, intravenous drug abuse and age ≤60 years were associated with GT1a infection (OR: 4.79; 95% CI: 2.43-9.47, p <0.001 and OR: 5.07; 95CI: 2.25-11.40, p<0.001, respectively), while age ≤60 years was the only risk factor for GT3 (OR: 15.81; 95CI: 4.76-52.54, p <0.001). In the Campania region, we observed an increase in GT1a and GT3 rates compared with those observed in previous years. Age ≤60 was an independent risk factor for GT1a and GT3 infection. Intravenous drug use was independently associated with GT1a infection.
丙型肝炎病毒（HCV）在全球广泛传播。意大利南部是一个高流行地区，HCV基因型（GTs）的分布正在发生变化。静脉注射吸毒是与特定HCV GT（GT3）相关的唯一危险因素。本研究的目的是评估特定HCV GTs的分布及危险因素。2017年1月至3月期间，共纳入682例血清HCV-RNA可测的患者。我们记录了临床信息及HCV危险因素的存在情况。GT1b是我们患者中的主要基因型（59.8%）。HCV GT1a和GT3感染在≤60岁的患者中更为常见（分别为14.9%对2.2%，p<0.01和13.6%对0.8%，p<0.01）。多因素分析显示，静脉注射吸毒和年龄≤60岁与GT1a感染相关（OR分别为：4.79；95%CI：2.43 - 9.47，p<0.001和OR：5.07；95CI：2.25 - 11.40，p<0.001），而年龄≤60岁是GT3的唯一危险因素（OR：15.81；95CI：4.76 - 52.54，p<0.001）。在坎帕尼亚地区，我们观察到与前几年相比，GT1a和GT3的感染率有所上升。年龄≤60岁是GT1a和GT3感染的独立危险因素。静脉注射吸毒与GT1a感染独立相关。
