小 RNA 作为形态发生素翻开新的一页。
Small RNAs Turn Over a New Leaf as Morphogens.
机构信息
Weill Institute for Cell and Molecular Biology and School of Integrative Plant Science, Section of Plant Biology, Cornell University, Ithaca, NY, USA.
Weill Institute for Cell and Molecular Biology and School of Integrative Plant Science, Section of Plant Biology, Cornell University, Ithaca, NY, USA.
出版信息
Dev Cell. 2017 Nov 6;43(3):253-254. doi: 10.1016/j.devcel.2017.10.025.
In this issue of Developmental Cell, Skopelitis et al. (2017) demonstrate that sharp boundaries of gene expression can be created by threshold-based readout of mobile small RNA gradients. Support for this hypothesis comes from manipulation of small RNAs involved in top-bottom leaf patterning and from a novel synthetic biology approach.
在本期《发育细胞》中，Skopelitis 等人（2017）证明，通过基于阈值的移动小 RNA 梯度读出，可以创建基因表达的锐利边界。支持这一假说的证据来自于对涉及上下叶片模式形成的小 RNA 的操作，以及一种新的合成生物学方法。
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