Avorn J, Dreyer P, Connelly K, Soumerai S B
Program for the Analysis of Clinical Strategies, Harvard Medical School, Boston, MA 02115.
N Engl J Med. 1989 Jan 26;320(4):227-32. doi: 10.1056/NEJM198901263200406.
Rest homes have become a major component of the health care system for frail elderly persons and deinstitutionalized psychiatric patients. Although psychoactive medications are frequently used in rest homes, there is little detailed information about the extent of such use, its supervision, or its effects. In a survey of a random sample of 55 rest homes in Massachusetts, we found that 55 percent of the residents were taking at least one psychoactive medication. Antipsychotic medications were being administered to 39 percent; of these, 18 percent were receiving two or more such drugs. In a follow-up investigation, we studied 837 residents in 44 rest homes with particularly high levels of antipsychotic-drug use. About half the residents had no evidence of participation by a physician in decisions about their mental health during the year of the study. A third of the residents had performance deficits on mental-status testing that indicated serious cognitive impairment, although the causal relation of such impairment to medication use could not be determined. Six percent had evidence of moderate or severe tardive dyskinesia, probably as a side effect of medication. An assessment of staff competence revealed a low level of comprehension of the purpose and side effects of commonly used psychoactive drugs. We conclude that psychoactive drugs are widely used in rest homes, with little medical supervision or understanding by staff members of their possible side effects.
养老院已成为体弱老年人和非机构化精神病患者医疗保健系统的一个主要组成部分。尽管精神活性药物在养老院中经常使用,但关于此类药物使用范围、监管情况或其效果的详细信息却很少。在对马萨诸塞州55家养老院的随机样本进行的一项调查中,我们发现55%的居民至少服用一种精神活性药物。39%的居民正在服用抗精神病药物;其中,18%的居民正在服用两种或更多此类药物。在一项后续调查中,我们研究了44家抗精神病药物使用水平特别高的养老院中的837名居民。在研究年度,约一半的居民没有医生参与其心理健康决策的证据。三分之一的居民在精神状态测试中存在表现缺陷,表明有严重的认知障碍,尽管无法确定这种障碍与药物使用之间的因果关系。6%的居民有中度或重度迟发性运动障碍的迹象,这可能是药物的副作用。对工作人员能力的评估显示,他们对常用精神活性药物的用途和副作用的理解水平较低。我们得出结论,精神活性药物在养老院中广泛使用,但很少有医疗监督,工作人员对其可能的副作用也了解甚少。