Boston J L, Beauchene R E, Cruikshank D P
Department of Obstetrics and Gynecology, Medical College of Virginia, Virginia Commonwealth University, Richmond.
Obstet Gynecol. 1989 Feb;73(2):169-74.
A prospective study of 53 nulliparous teenagers was conducted to determine differences in erythrocyte and plasma magnesium concentrations between subjects who had normal full-term deliveries (normal pregnant group) and those who developed pregnancy-induced hypertension. Magnesium content of monthly blood samples was determined by atomic absorption spectrophotometry. Socioeconomic data and information on use of supplements, medicines, tobacco, and alcohol were obtained by interview and medical chart review. Erythrocyte magnesium levels in both groups remained stable during pregnancy, whereas plasma magnesium showed a slight decline (P less than .08). Plasma and erythrocyte magnesium did not differ significantly between the normal pregnant (N = 30) and pregnancy-induced hypertension (N = 12) groups. Overall, mean arterial pressure was not significantly related to plasma or erythrocyte magnesium values. Within the pregnancy-induced hypertension group, there was a slight (P less than .05) inverse relationship between mean arterial pressure and plasma magnesium. The two groups were similar for socioeconomic characteristics, gynecologic age, previous use of oral contraceptives, and use of tobacco and magnesium-containing supplements. Pregnancy-induced hypertension subjects reported more alcohol use than did normal pregnant subjects (P less than .02). In conclusion, there was no evidence of magnesium depletion among teens who developed pregnancy-induced hypertension, by measurement of erythrocyte or plasma magnesium.
对53名未生育的青少年进行了一项前瞻性研究，以确定正常足月分娩的受试者（正常妊娠组）和发生妊娠高血压的受试者之间红细胞和血浆镁浓度的差异。每月采集的血样中的镁含量通过原子吸收分光光度法测定。通过访谈和查阅病历获得社会经济数据以及关于补充剂、药物、烟草和酒精使用的信息。两组的红细胞镁水平在孕期均保持稳定，而血浆镁水平略有下降（P<0.08）。正常妊娠组（n=30）和妊娠高血压组（n=12）之间的血浆镁和红细胞镁无显著差异。总体而言，平均动脉压与血浆或红细胞镁值无显著相关性。在妊娠高血压组中，平均动脉压与血浆镁之间存在轻微的负相关（P<0.05）。两组在社会经济特征、妇科年龄、既往口服避孕药使用情况以及烟草和含镁补充剂的使用方面相似。妊娠高血压受试者报告的酒精使用量高于正常妊娠受试者（P<0.02）。总之，通过测量红细胞或血浆镁，未发现发生妊娠高血压的青少年存在镁缺乏的证据。
