Campbell N R, Ashley M J, Carruthers S G, Lacourcière Y, McKay D W
Division of General Internal Medicine, University of Calgary, Alta.
CMAJ. 1999 May 4;160(9 Suppl):S13-20.
To provide updated, evidence-based recommendations concerning the effects of alcohol consumption on the prevention and control of hypertension in otherwise healthy adults (except pregnant women).
There are 2 main options for those at risk for hypertension: avert the condition by limiting alcohol consumption or by using other nonpharmacologic methods, or maintain or increase the risk of hypertension by making no change in alcohol consumption. The options for those who already have hypertension include decreasing alcohol consumption or using another nonpharmacologic method to reduce hypertension; commencing, continuing or intensifying antihypertensive medication; or taking no action and remaining at increased risk of cardiovascular disease.
The health outcomes considered were changes in blood pressure and in morbidity and mortality rates. Because of insufficient evidence, no economic outcomes were considered.
A MEDLINE search was conducted for the period 1966-1996 with the terms ethyl alcohol and hypertension. Other relevant evidence was obtained from the reference lists of articles identified, from the personal files of the authors and through contacts with experts. The articles were reviewed, classified according to study design, and graded according to the level of evidence.
A high value was placed on the avoidance of cardiovascular morbidity and premature death caused by untreated hypertension.
BENEFITS, HARMS AND COSTS: A reduction in alcohol consumption from more than 2 standard drinks per day reduces the blood pressure of both hypertensive and normotensive people. The lowest overall mortality rates in observational studies were associated with drinking habits that were within these guidelines. Side effects and costs were not measured in any of the studies.
(1) It is recommended that health care professionals determine how much alcohol their patients consume. (2) To reduce blood pressure in the population at large, it is recommended that alcohol consumption be in accordance with Canadian low-risk drinking guidelines (i.e., healthy adults who choose to drink should limit alcohol consumption to 2 or fewer standard drinks per day, with consumption not exceeding 14 standard drinks per week for men and 9 standard drinks per week for women). (3) Hypertensive patients should also be advised to limit alcohol consumption to the levels set out in the Canadian low-risk drinking guidelines.
These recommendations are similar to those of the World Hypertension League, the National High Blood Pressure Education Program Working Group on Primary Prevention of Hypertension and the previous recommendations of the Canadian Coalition for High Blood Pressure Prevention and Control and the Canadian Hypertension Society. They have not been clinically tested. The low-risk drinking guidelines are those of the Addiction Research Foundation of Ontario and the Canadian Centre on Substance Abuse.
The Canadian Hypertension Society, the Canadian Coalition for High Blood Pressure Prevention and Control, the Laboratory Centre for Disease Control at Health Canada, and the Heart and Stroke Foundation of Canada. The low-risk drinking guidelines have been endorsed by the College of Family Physicians of Canada and several provincial organizations.
针对饮酒对健康成年人(孕妇除外)高血压预防与控制的影响,提供最新的循证建议。
高血压风险人群有两种主要选择:通过限制饮酒或采用其他非药物方法预防该病,或者不改变饮酒习惯维持或增加患高血压风险。已患高血压者的选择包括减少饮酒或采用其他非药物方法降低血压;开始、持续或加强使用抗高血压药物;或者不采取行动,维持心血管疾病的高风险状态。
所考虑的健康结果为血压变化以及发病率和死亡率变化。由于证据不足,未考虑经济结果。
检索了1966年至1996年期间MEDLINE数据库中有关乙醇和高血压的文献。从已识别文章的参考文献列表、作者个人档案以及与专家的联系中获取了其他相关证据。对文章进行了评审,根据研究设计进行分类,并根据证据水平进行分级。
高度重视避免因未治疗的高血压导致的心血管疾病发病率和过早死亡。
益处、危害和成本:每天饮酒量从超过2标准杯减少,可降低高血压患者和血压正常者的血压。观察性研究中总体死亡率最低的情况与符合这些指南的饮酒习惯相关。所有研究均未测量副作用和成本。
(1)建议医疗保健专业人员确定其患者的饮酒量。(2)为降低总体人群的血压,建议饮酒量符合加拿大低风险饮酒指南(即选择饮酒的健康成年人应将饮酒量限制在每天2标准杯或更少,男性每周饮酒量不超过14标准杯,女性每周不超过9标准杯)。(3)还应建议高血压患者将饮酒量限制在加拿大低风险饮酒指南规定的水平。
这些建议与世界高血压联盟、国家高血压教育计划原发性高血压预防工作组以及加拿大高血压预防与控制联盟和加拿大高血压协会先前的建议相似。它们尚未经过临床检验。低风险饮酒指南是安大略省成瘾研究基金会和加拿大药物滥用中心制定的。
加拿大高血压协会、加拿大高血压预防与控制联盟、加拿大卫生部疾病控制实验室中心以及加拿大心脏与中风基金会。低风险饮酒指南已得到加拿大家庭医生学院和几个省级组织的认可。