Cai T Y, Qasem A, Ayer J G, Butlin M, O'Meagher S, Melki C, Marks G B, Avolio A, Celermajer D S, Skilton M R
Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders, University of Sydney, Sydney, NSW, Australia.
J Hum Hypertens. 2017 Dec;31(12):831-837. doi: 10.1038/jhh.2017.59. Epub 2017 Aug 24.
Central blood pressure can be estimated from peripheral pulses in adults using generalised transfer functions (TF). We sought to create and test age-specific non-invasively developed TFs in children, with comparison to a pre-existing adult TF. We studied healthy children from two sites at two time points, 8 and 14 years of age, split by site into development and validation groups. Radial and carotid pressure waveforms were obtained by applanation tonometry. Central systolic pressure was derived from carotid waveforms calibrated to brachial mean and diastolic pressures. Age-specific TFs created in the development groups (n=50) were tested in the validation groups aged 8 (n=137) and 14 years (n=85). At 8 years of age, the age-specific TF estimated 82, 99 and 100% of central systolic pressure values within 5, 10 and 15 mm Hg of their measured values, respectively. This TF overestimated central systolic pressure by 2.2 (s.d. 3.7) mm Hg, compared to being underestimated by 5.6 (s.d. 3.9) mm Hg with the adult TF. At 14 years of age, the age-specific TF estimated 60, 87 and 95% of values within 5, 10 and 15 mm Hg of their measured values, respectively. This TF underestimated central systolic pressure by 0.5 (s.d. 6.7) mm Hg, while the adult TF underestimated it by 6.8 (s.d. 6.0) mm Hg. In conclusion, age-specific TFs more accurately predict central systolic pressure measured at the carotid artery in children than an existing adult TF.
使用广义传递函数（TF）可以从成人的外周脉搏估计中心血压。我们试图创建并测试针对儿童的非侵入性开发的特定年龄TF，并与现有的成人TF进行比较。我们在两个时间点对来自两个地点的健康儿童进行了研究，年龄分别为8岁和14岁，按地点分为开发组和验证组。通过压平式眼压计获得桡动脉和颈动脉压力波形。中心收缩压由校准至肱动脉平均压和舒张压的颈动脉波形得出。在开发组（n = 50）中创建的特定年龄TF在8岁（n = 137）和14岁（n = 85）的验证组中进行了测试。在8岁时，特定年龄TF分别估计了其测量值的5、10和15 mmHg范围内82%、99%和100%的中心收缩压值。与成人TF低估5.6（标准差3.9）mmHg相比，该TF高估中心收缩压2.2（标准差3.7）mmHg。在14岁时，特定年龄TF分别估计了其测量值的5、10和15 mmHg范围内60%、87%和95%的中心收缩压值。该TF低估中心收缩压0.5（标准差6.7）mmHg，而成人TF低估6.8（标准差6.0）mmHg。总之，与现有的成人TF相比，特定年龄TF能更准确地预测儿童颈动脉测量的中心收缩压。
