Mihuta Monica Simina, Paul Corina, Borlea Andreea, Cepeha Cristina Mihaela, Velea Iulian Puiu, Mozos Ioana, Stoian Dana
Department of Doctoral Studies, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Department of Pediatrics, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.
J Clin Med. 2022 Aug 29;11(17):5078. doi: 10.3390/jcm11175078.
Early detection of all complications of childhood obesity is imperative in order to minimize effects. Obesity causes vascular disruptions, including early increased arterial stiffness and high blood pressure. This study's aim is to assess the reliability of pulse wave analysis (PWA) in obese children and how additional risk factors influence the evaluated parameters. We analyzed 55 children aged 6-18 years old by measuring their pulse wave velocity (PWV), augmentation index (AIx), peripheral blood pressure (SBP, DBP), heart rate, central blood pressure (cSBP, cDBP) and central pulse pressure (cPP). We used the oscillometric IEM Mobil-O-Graph and performed a single-point brachial measurement. The subjects were divided into two groups: obese ( = 30) and normal-weight ( = 25) and were clinically and anamnestically assessed. BMI and waist circumference are significantly correlated to higher values for PWV, SBP, DBP, cSBP, and cDBP. Weight significantly predicts PWV, SBP, DBP and cPP. The risk factors that significantly influence the PWA and BP values are: a cardiometabolically risky pregnancy (higher PWV, AIx, SBP), active and passive smoking (higher PWV, SBP, cSBP, cDBP), sleep deprivation (higher PWV, SBP, cSBP) and sedentariness (higher PWV, AIx, peripheral and central BP). We conclude that obese children with specific additional cardiometabolic risk factors present increased arterial stiffness and higher blood pressure values.
为了将影响降至最低，早期发现儿童肥胖的所有并发症势在必行。肥胖会导致血管紊乱，包括早期动脉僵硬度增加和高血压。本研究的目的是评估脉搏波分析（PWA）在肥胖儿童中的可靠性，以及其他风险因素如何影响所评估的参数。我们通过测量55名6至18岁儿童的脉搏波速度（PWV）、增强指数（AIx）、外周血压（收缩压、舒张压）、心率、中心血压（中心收缩压、中心舒张压）和中心脉压（中心PP）进行分析。我们使用示波法IEM Mobil-O-Graph并进行单点肱动脉测量。受试者分为两组：肥胖组（n = 30）和正常体重组（n = 25），并进行了临床和病史评估。体重指数和腰围与PWV、收缩压、舒张压、中心收缩压和中心舒张压的较高值显著相关。体重显著预测PWV、收缩压、舒张压和中心PP。显著影响PWA和血压值的风险因素包括：具有心脏代谢风险的妊娠（较高的PWV、AIx、收缩压）、主动和被动吸烟（较高的PWV、收缩压、中心收缩压、中心舒张压）、睡眠不足（较高的PWV、收缩压、中心收缩压）和久坐不动（较高的PWV、AIx、外周和中心血压）。我们得出结论，具有特定额外心脏代谢风险因素的肥胖儿童存在动脉僵硬度增加和血压值升高的情况。
