NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center , Maastricht , The Netherlands.
Department of Human Biology and Human Movement Sciences, Maastricht University Medical Center , Maastricht , The Netherlands.
Am J Physiol Endocrinol Metab. 2018 Feb 1;314(2):E165-E173. doi: 10.1152/ajpendo.00266.2017. Epub 2017 Nov 7.
Exercise training reduces intrahepatic lipid (IHL) content in people with elevated liver fat content. It is unclear, however, whether exercise training reduces IHL content in people with normal liver fat content. Here, we measured the effect of exercise training on IHL content in people with and people without nonalcohol fatty liver. We further measured changes in insulin sensitivity and hepatic energy metabolism. Eleven males with nonalcoholic fatty liver (NAFL) and 11 body mass index-matched individuals without nonalcoholic fatty liver (CON) completed a 12-wk supervised exercise training program. IHL content (proton magnetic resonance spectroscopy), maximal oxidative capacity (V̇o, spiroergometry), total muscle strength, body composition, insulin sensitivity (hyperinsulinemic-euglycemic clamp), hepatic ATP-to-total phosphorus ratio, and the hepatic phosphomonoester-to-phosphodiester (PME/PDE) ratio (phosphorus magnetic resonance spectroscopy) were determined. IHL content reduced with exercise training ( P = 0.014) in the whole study population. The relative reduction in IHL content was comparable in NAFL (-34.5 ± 54.0%) and CON (-28.3 ± 60.1%) individuals ( P = 0.800). V̇o ( P < 0.001), total muscle strength ( P < 0.001), and skeletal muscle insulin sensitivity ( P = 0.004) increased, whereas adipose tissue ( P = 0.246) and hepatic ( P = 0.086) insulin sensitivity did not increase significantly. Hepatic ATP-to-total phosphorus ratio ( P = 0.987) and PME/PDE ratio ( P = 0.792) did not change. Changes in IHL content correlated with changes in body weight ( r = 0.451, P = 0.035) and changes in hepatic PME/PDE ratio ( r = 0.569, P = 0.019). In conclusion, exercise training reduced intrahepatic lipid content in people with nonalcoholic fatty liver and in people with normal intrahepatic lipid content, and the percent reduction in intrahepatic lipid content was similar in both groups.
运动训练可降低肝脏脂肪含量升高人群的肝内脂质（IHL）含量。然而，运动训练是否可降低肝脏脂肪含量正常人群的 IHL 含量尚不清楚。在此，我们检测了运动训练对非酒精性脂肪肝（NAFL）和非酒精性脂肪肝（CON）个体的 IHL 含量的影响。我们还检测了胰岛素敏感性和肝能量代谢的变化。11 名男性 NAFL 患者和 11 名体重指数匹配的无 NAFL 个体（CON）完成了 12 周的监督运动训练计划。通过质子磁共振波谱法测定 IHL 含量、最大氧化能力（V̇o，呼吸气体分析仪）、总肌肉力量、身体成分、胰岛素敏感性（高胰岛素-正葡萄糖钳夹）、肝 ATP 与总磷比和肝磷酸单酯-磷酸二酯（PME/PDE）比（磷磁共振波谱法）。IHL 含量随运动训练而降低（P = 0.014）。NAFL（-34.5 ± 54.0%）和 CON（-28.3 ± 60.1%）个体的 IHL 含量相对减少（P = 0.800）。V̇o（P < 0.001）、总肌肉力量（P < 0.001）和骨骼肌胰岛素敏感性（P = 0.004）增加，而脂肪组织（P = 0.246）和肝胰岛素敏感性（P = 0.086）无明显增加。肝 ATP 与总磷比（P = 0.987）和 PME/PDE 比（P = 0.792）未改变。IHL 含量的变化与体重变化（r = 0.451，P = 0.035）和肝 PME/PDE 比的变化（r = 0.569，P = 0.019）相关。总之，运动训练降低了非酒精性脂肪肝和肝脏脂肪含量正常人群的肝内脂质含量，两组人群的 IHL 含量减少百分比相似。
