Monserrat-Mesquida Margalida, Quetglas-Llabrés Magdalena, Bouzas Cristina, Montemayor Sofía, Mascaró Catalina M, Casares Miguel, Llompart Isabel, Gámez José M, Tejada Silvia, Martínez J Alfredo, Tur Josep A, Sureda Antoni
Research Group in Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain.
Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.
Antioxidants (Basel). 2022 Jun 27;11(7):1266. doi: 10.3390/antiox11071266.
Non-alcoholic fatty liver disease (NAFLD) is a disorder characterized by the excessive accumulation of lipids in the liver parenchyma. To date, there is no effective pharmacological treatment against NAFLD. Objective: To assess the relationship between the improvement of the intrahepatic fat content (IFC) in patients with NAFLD and metabolic syndrome and biomarkers of oxidative stress and inflammation after 6 months of lifestyle intervention. Patients diagnosed with NAFLD ( = 60 adults; 40-60 years old) residing in the Balearic Islands, Spain, were distributed in tertiles attending the improvement of IFC calculated by magnetic resonance imaging (MRI). Anthropometrics, blood pressure, maximal oxygen uptake, and pro/antioxidant and inflammatory biomarkers were determined in plasma before and after the lifestyle intervention. The improvement in IFC levels was higher in tertile 3 with respect to tertiles 2 and 1. The greatest improvement in IFC is related to cardiorespiratory fitness and adherence to the Mediterranean diet (ADM). Higher reductions in weight, body mass index (BMI), and alanine aminotransferase (ALT) were observed in tertile 3 with respect to tertile 1 after 6 months of intervention. The improvement in catalase, irisin, and cytokeratin 18 plasma levels were higher in tertile 3, whereas no differences were observed in superoxide dismutase activity. Malondialdehyde and protein carbonyl levels, as biomarkers of oxidative damage, remained unchanged in all groups. The present data show that the reduction of IFC is associated with an improvement in pro/antioxidant and pro-inflammatory status and a better cardiorespiratory fitness in NAFLD patients.
非酒精性脂肪性肝病（NAFLD）是一种以肝实质中脂质过度蓄积为特征的病症。迄今为止，尚无针对NAFLD的有效药物治疗方法。目的：评估非酒精性脂肪性肝病患者肝内脂肪含量（IFC）的改善与代谢综合征以及生活方式干预6个月后氧化应激和炎症生物标志物之间的关系。居住在西班牙巴利阿里群岛、被诊断为NAFLD的患者（n = 60名成年人；40 - 60岁），根据磁共振成像（MRI）计算的IFC改善情况分为三分位数组。在生活方式干预前后测定血浆中的人体测量指标、血压、最大摄氧量以及促氧化剂/抗氧化剂和炎症生物标志物。与第2和第1三分位数组相比，第3三分位数组的IFC水平改善更高。IFC的最大改善与心肺适能和对地中海饮食（ADM）的依从性有关。干预6个月后，与第1三分位数组相比，第3三分位数组的体重减轻、体重指数（BMI）和丙氨酸氨基转移酶（ALT）降低幅度更大。第3三分位数组的过氧化氢酶、鸢尾素和细胞角蛋白18血浆水平改善更高，而超氧化物歧化酶活性未观察到差异。作为氧化损伤生物标志物的丙二醛和蛋白质羰基水平在所有组中均保持不变。目前的数据表明，NAFLD患者中IFC的降低与促氧化剂/抗氧化剂和促炎状态的改善以及更好的心肺适能相关。
