缺氧耐受和耐热性之间存在正遗传相关性，这支持了一种有争议的热应激理论。
A positive genetic correlation between hypoxia tolerance and heat tolerance supports a controversial theory of heat stress.
机构信息
School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA.
School of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA.
出版信息
Biol Lett. 2017 Nov;13(11). doi: 10.1098/rsbl.2017.0309.
Abstract
We used quantitative genetics to test a controversial theory of heat stress, in which animals overheat when the demand for oxygen exceeds the supply. This theory, referred to as oxygen- and capacity-limited thermal tolerance, predicts a positive genetic correlation between hypoxia tolerance and heat tolerance. We demonstrate the first genetic correlation of this kind in a model organism, Genotypes more likely to fly under hypoxic stress (12% O) were also more likely to fly under heat stress (39°C). This finding prompts new questions about mechanisms and limits of adaptation to heat stress.
摘要
我们运用数量遗传学验证了一个颇具争议的热应激理论，该理论认为动物在耗氧量超过供应量时会过热。这个理论被称为氧气和能力限制的热耐受，预测了低氧耐受性和耐热性之间存在正的遗传相关性。我们在一个模式生物中首次证明了这种遗传相关性，在低氧应激（12% O）下更有可能飞行的基因型在热应激（39°C）下也更有可能飞行。这一发现引发了关于适应热应激的机制和限制的新问题。
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