Department of Development and Regeneration, KU Leuven, Leuven, Belgium.
Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium.
Ultrasound Obstet Gynecol. 2018 Aug;52(2):269-278. doi: 10.1002/uog.18951.
To identify ultrasound features of papillations or of the cyst wall that can discriminate between benign and malignant unilocular-solid cysts with papillations but no other solid components.
From the International Ovarian Tumor Analysis (IOTA) database derived from seven ultrasound centers, we identified patients with an adnexal lesion described at ultrasonography as unilocular-solid with papillations but no other solid components. All patients had undergone transvaginal ultrasound between 1999 and 2007 or 2009 and 2012, by an experienced examiner following the IOTA research protocol. Information on four ultrasound features of papillations had been collected prospectively. Information on a further seven ultrasound features was collected retrospectively from electronic or paper ultrasound images of good quality. The histological diagnosis of the surgically removed adnexal lesion was considered the gold standard.
Of 204 masses included, 131 (64.2%) were benign, 42 (20.6%) were borderline tumors, 30 (14.7%) were primary invasive tumors and one (0.5%) was a metastasis. Multivariate logistic regression analysis showed the following ultrasound features to be associated independently with malignancy: height of the largest papillation, presence of blood flow in papillations, papillation confluence or dissemination, and shadows behind papillations. Shadows decreased the odds of malignancy, while the other features increased them.
We have identified ultrasound features that can help to discriminate between benign and malignant unilocular-solid cysts with papillations but no other solid components. Our results need to be confirmed in prospective studies. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
确定乳头状突起或囊肿壁的超声特征，以区分具有乳头状突起但无其他实性成分的良性和恶性单房性实性囊肿。
我们从七个超声中心的国际卵巢肿瘤分析（IOTA）数据库中，确定了在超声检查中描述为具有乳头状突起的单房性实性但无其他实性成分的附件病变患者。所有患者均在 1999 年至 2007 年或 2009 年至 2012 年期间，由经验丰富的检查者按照 IOTA 研究方案进行了经阴道超声检查。前瞻性收集了关于乳头状突起的四个超声特征的信息。从质量较好的电子或纸质超声图像中回顾性收集了另外七个超声特征的信息。手术切除的附件病变的组织学诊断被认为是金标准。
204 个肿块中，131 个（64.2%）为良性，42 个（20.6%）为交界性肿瘤，30 个（14.7%）为原发性浸润性肿瘤，1 个（0.5%）为转移瘤。多变量逻辑回归分析显示，以下超声特征与恶性肿瘤独立相关：最大乳头状突起的高度、乳头状突起内血流的存在、乳头状突起融合或播散、乳头状突起后的阴影。阴影降低了恶性肿瘤的可能性，而其他特征则增加了这种可能性。
我们已经确定了一些超声特征，可以帮助区分具有乳头状突起但无其他实性成分的良性和恶性单房性实性囊肿。我们的结果需要在前瞻性研究中得到证实。版权所有 © 2017 ISUOG。由 John Wiley & Sons Ltd 出版。
