Rönnholm K A, Dostálová L, Siimes M A
Children's Hospital, University of Helsinki, Finland.
Am J Clin Nutr. 1989 Jan;49(1):121-6. doi: 10.1093/ajcn/49.1.121.
This study evaluates the need of vitamin E supplementation in very-low-birth-weight infants by long-term follow-up of plasma vitamin E status during the first 15 mo of life, with two different levels of supplementation. The subjects were 51 newborn infants with birth weights less than or equal to 1520 g. During hospitalization the infants were fed human milk. On the third day of life oral vitamin E supplementation of less than or equal to 10 mg/d was started in all infants. In addition, 23 infants selected at random were given intramuscular vitamin E (20 mg/kg/d) during the first 3 d. The data indicate that the 10 mg/d supplement resulted in an adequate plasma concentration of vitamin E. After cessation of supplementation at age 3 mo, the risk of low plasma vitamin E levels increased. Although intramuscular administration resulted in long-lasting increments in mean plasma vitamin E values, some later levels in these infants were marginal.
本研究通过对极低出生体重儿出生后15个月内血浆维生素E水平进行长期随访，并采用两种不同的补充水平，评估其补充维生素E的必要性。研究对象为51名出生体重小于或等于1520g的新生儿。住院期间，这些婴儿接受母乳喂养。在出生后第三天，所有婴儿开始口服补充维生素E，剂量小于或等于10mg/d。此外，随机选择的23名婴儿在出生后的前3天接受肌肉注射维生素E（20mg/kg/d）。数据表明，每天补充10mg维生素E可使血浆维生素E浓度达到充足水平。在3个月龄停止补充后，血浆维生素E水平降低的风险增加。虽然肌肉注射导致血浆维生素E平均水平持续升高，但这些婴儿后期的一些水平仍处于临界状态。
