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剖宫产术后使用球囊导管或缩宫素引产的安全性和有效性。

Safety and effectiveness of labour induction after caesarean section using balloon catheter or oxytocin.

作者信息

Radan Anda-Petronela, Amylidi-Mohr Sofia, Mosimann Beatrix, Simillion Cedric, Raio Luigi, Mueller Martin, Surbek Daniel

机构信息

Department of Obstetrics and Gynaecology, University Hospital and University of Bern, Switzerland.

Department of Biomedical Research, University of Bern, Switzerland.

出版信息

Swiss Med Wkly. 2017 Nov 8;147:w14532. doi: 10.4414/smw.2017.14532. eCollection 2017.

Abstract

AIMS OF THE STUDY

Induction of labour after previous caesarean section (CS) is a challenge for obstetricians due to the increased risk of uterine rupture. Common methods for labour induction are balloon catheters and oxytocin as they are considered safe. However, the effectiveness remains unclear as currently available data are limited. Therefore, we aimed to determine safety and effectiveness of balloon catheter or oxytocin for labour induction after CS.

METHODS

We included 179 consecutive women with a previous CS and labour induction in this retrospective study. We performed labour induction using a balloon catheter in case of a Bishop score of <6 and intact membranes, or oxytocin in the case of a Bishop score of >6 and/or premature rupture of membranes. The primary outcome was the rate of successful vaginal deliveries. We adjusted for multiple factors that may have impacted on the rate of vaginal delivery as well. The secondary outcomes were the rate of maternal and neonatal morbidities.

RESULTS

We detected a vaginal delivery success rate of 45.8% in the catheter and of 63.9% in the oxytocin group. We identified previous vaginal birth as an independent predictive factor for successful vaginal delivery in both groups. Induction using oxytocin was a negative predictive factor for neonatal admissions. Multivariate analysis showed that post-term pregnancy decreased the likelihood of vaginal delivery. We did not detect any factors predicting uterine rupture or uterine dehiscence, which occurred with similar frequency in both groups. Finally, the neonatal admission rate was less likely with higher gestational age and oxytocin as an induction method, whereas previous vaginal birth increased the risk.

CONCLUSIONS

Our study indicates that induction of labour with balloon catheter or oxytocin seems to be safe in women with previous CS. Labour induction using a balloon catheter in women with previous CS and unfavourable cervix has a disappointingly low success rate. We identified factors influencing vaginal delivery success rates. Women with previous CS and indications for labour induction should be informed about vaginal birth success rates and the alternative of elective repeat CS needs to be discussed.

摘要

研究目的

由于子宫破裂风险增加,既往剖宫产术后引产对产科医生而言是一项挑战。引产的常用方法是球囊导管和缩宫素,因为它们被认为是安全的。然而,由于目前可得的数据有限,其有效性仍不明确。因此,我们旨在确定球囊导管或缩宫素用于既往剖宫产术后引产的安全性和有效性。

方法

在这项回顾性研究中,我们纳入了179例既往有剖宫产史且进行引产的连续病例。如果 Bishop 评分<6 且胎膜完整,我们使用球囊导管进行引产;如果 Bishop 评分>6 和/或胎膜早破,则使用缩宫素。主要结局是阴道分娩成功率。我们还对可能影响阴道分娩率的多个因素进行了校正。次要结局是孕产妇和新生儿发病率。

结果

我们发现球囊导管组的阴道分娩成功率为 45.8%,缩宫素组为 63.9%。我们确定既往经阴道分娩是两组阴道分娩成功的独立预测因素。使用缩宫素引产是新生儿入院的负性预测因素。多因素分析显示过期妊娠会降低阴道分娩的可能性。我们未发现任何预测子宫破裂或子宫裂开的因素,两组中这些情况的发生频率相似。最后,孕周越大且以缩宫素作为引产方法时,新生儿入院率越低,而既往经阴道分娩则会增加风险。

结论

我们的研究表明,对于既往有剖宫产史的女性,使用球囊导管或缩宫素引产似乎是安全的。对于既往有剖宫产史且宫颈条件不佳的女性,使用球囊导管引产的成功率低得令人失望。我们确定了影响阴道分娩成功率的因素。应告知既往有剖宫产史且有引产指征的女性阴道分娩成功率,并讨论择期再次剖宫产的替代方案。

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