Hetta Helal F, Elkady Azza, Morsy Khairy H, Mohamed Ismael S, Ibrahim Maggie A
Department of Medical Microbiology & Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Sohag general Hospital, Sohag University, Sohag, Egypt.
Egypt J Immunol. 2017 Jan;24(1):79-88.
IL17a is the key inflammatory cytokine of TH17 and contributes to the pathogenesis of diabetes mellitus which is a common endocrine disorder associated with HCV infection. Herein, 183 cirrhotic HCV infected patients were screened for ANA by ELISA and positive cases (n=40) were screened for ICA by Immunofluorescence and IL17a serum levels were measured by ELISA and compared to a control group (n=24). Out of 40 cirrhotic HCV, ANA (+) infected patients, 16 patients (40 %) were type 2 diabetic and 13 (32.5%) were non-diabetic. On the other hand, 17 positive ICA (42.5%) and 23 negative ICA (57.5%) patients were reported. IL17a serum level was significantly elevated in cirrhotic HCV infected patients who were positive for ICA than negative ICA (P < 0.0001) and was significantly higher in type 2 diabetic than both non-diabetic patients (P=0.04) and controls (P=0.0005). In conclusion, IL17 serum levels were elevated in diabetic HCV infected patients.
IL17a是TH17关键的炎性细胞因子，在糖尿病发病机制中起作用，糖尿病是一种与丙型肝炎病毒（HCV）感染相关的常见内分泌疾病。在此，通过酶联免疫吸附测定（ELISA）对183例HCV感染的肝硬化患者进行抗核抗体（ANA）筛查，对阳性病例（n = 40）通过免疫荧光法进行胰岛细胞抗体（ICA）筛查，并通过ELISA测定IL17a血清水平，与对照组（n = 24）进行比较。在40例HCV感染的肝硬化ANA（+）患者中，16例（40%）为2型糖尿病患者，13例（32.5%）为非糖尿病患者。另一方面，报告了17例ICA阳性患者（42.5%）和23例ICA阴性患者（57.5%）。ICA阳性的HCV感染肝硬化患者的IL17a血清水平显著高于ICA阴性患者（P < 0.0001），2型糖尿病患者的IL17a血清水平显著高于非糖尿病患者（P = 0.04）和对照组（P = 0.0005）。总之，糖尿病HCV感染患者的IL17血清水平升高。
